Table 3.

Complement gene sets in neutrophils and lymphocytes

Neutrophils
GO complement–related gene setsNeutrophil high vs lowP value
Complement activation 46/76  1.00E-24  
Complement activation, classical pathway 44/63 1.00E-24 
Complement receptor–mediated signaling pathway 2/5 .0475 
Regulation of complement activation 46/72 1.00E-24 
Regulation of complement activation, lectin pathway 1/1 .0744 
Regulation of complement-dependent cytotoxicity 1/4 .266 
Negative regulation of complement activation 2/5 .0475 
Negative regulation of complement activation, lectin pathway 1/1 .0744 
Neutrophils
GO complement–related gene setsNeutrophil high vs lowP value
Complement activation 46/76  1.00E-24  
Complement activation, classical pathway 44/63 1.00E-24 
Complement receptor–mediated signaling pathway 2/5 .0475 
Regulation of complement activation 46/72 1.00E-24 
Regulation of complement activation, lectin pathway 1/1 .0744 
Regulation of complement-dependent cytotoxicity 1/4 .266 
Negative regulation of complement activation 2/5 .0475 
Negative regulation of complement activation, lectin pathway 1/1 .0744 
Lymphocytes
GO complement–related gene setsNeutrophil high vs lowP value
Complement activation 32/76  1.00E-24  
Complement activation, classical pathway 32/62 1.00E-24 
Regulation of complement activation 32/71 1.00E-24 
Lymphocytes
GO complement–related gene setsNeutrophil high vs lowP value
Complement activation 32/76  1.00E-24  
Complement activation, classical pathway 32/62 1.00E-24 
Regulation of complement activation 32/71 1.00E-24 

Ratio indicates the number of genes in the gene set that are significantly changed.

The P value represents the degree of change in RNA expression in the members of the gene set when comparing the messenger RNA changes from lymphocyte samples with NLR_High to NLR_Low.

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