Unadjusted cumulative incidences/estimates
| . | Older MUD (donor ≥35 y) . | Younger haploidentical (donor <35 y) . | ||
|---|---|---|---|---|
| Estimate (%) . | 95% CI . | Estimate (%) . | 95% CI . | |
| aGVHD grade 2-4, d 100 | 21.5 | 15.0-28.7 | 16.3 | 10.9-22.7 |
| aGVHD grade 3-4, d 100 | 8.4 | 4.9-13.1 | 4.2 | 1.8-8.0 |
| cGVHD | ||||
| 1 y | 48.6 | 41.8-55.1 | 26.4 | 20.3-32.9 |
| 2 y | 54.4 | 47.5-60.8 | 31.5 | 24.8-38.4 |
| 3 y | 55.1 | 48.1-61.5 | 33.9 | 26.7-41.2 |
| 4 y | 56.0 | 49.0-62.5 | 33.9 | 26.7-41.2 |
| NRM | ||||
| 1 y | 22.5 | 17.3-28.1 | 15.1 | 14.0-16.2 |
| 2 y | 28.1 | 22.4-34.2 | 19.0 | 17.8-20.2 |
| 3 y | 33.5 | 27.1-40.0 | 21.2 | 19.9-22.6 |
| 4 y | 35.2 | 28.5-42.0 | 22.4 | 21.0-23.9 |
| Relapse | ||||
| 1 y | 18.1 | 13.4-23.3 | 23.0 | 17.1-29.4 |
| 2 y | 21.8 | 16.7-27.4 | 32.7 | 25.7-39.8 |
| 3 y | 23.2 | 17.8-29.1 | 39.4 | 31.4-47.2 |
| 4 y | 24.1 | 18.5-30.2 | 41.7 | 32.8-50.3 |
| PFS | ||||
| 1 y | 59.4 | 52.8-65.5 | 67.5 | 60.2-73.8 |
| 2 y | 49.5 | 42.8-55.9 | 54.3 | 46.5-61.4 |
| 3 y | 42.8 | 35.9-49.6 | 45.9 | 37.7-53.8 |
| 4 y | 40.2 | 33.2-47.2 | 41.1 | 31.4-50.5 |
| OS | ||||
| 1 y | 71.5 | 65.2-76.8 | 82.2 | 75.9-87.0 |
| 2 y | 58.7 | 51.9-64.8 | 71.8 | 64.5-77.9 |
| 3 y | 50.2 | 43.1-56.8 | 66.3 | 58.2-73.2 |
| 4 y | 47.1 | 39.9-54.0 | 60.5 | 50.6-69.1 |
| . | Older MUD (donor ≥35 y) . | Younger haploidentical (donor <35 y) . | ||
|---|---|---|---|---|
| Estimate (%) . | 95% CI . | Estimate (%) . | 95% CI . | |
| aGVHD grade 2-4, d 100 | 21.5 | 15.0-28.7 | 16.3 | 10.9-22.7 |
| aGVHD grade 3-4, d 100 | 8.4 | 4.9-13.1 | 4.2 | 1.8-8.0 |
| cGVHD | ||||
| 1 y | 48.6 | 41.8-55.1 | 26.4 | 20.3-32.9 |
| 2 y | 54.4 | 47.5-60.8 | 31.5 | 24.8-38.4 |
| 3 y | 55.1 | 48.1-61.5 | 33.9 | 26.7-41.2 |
| 4 y | 56.0 | 49.0-62.5 | 33.9 | 26.7-41.2 |
| NRM | ||||
| 1 y | 22.5 | 17.3-28.1 | 15.1 | 14.0-16.2 |
| 2 y | 28.1 | 22.4-34.2 | 19.0 | 17.8-20.2 |
| 3 y | 33.5 | 27.1-40.0 | 21.2 | 19.9-22.6 |
| 4 y | 35.2 | 28.5-42.0 | 22.4 | 21.0-23.9 |
| Relapse | ||||
| 1 y | 18.1 | 13.4-23.3 | 23.0 | 17.1-29.4 |
| 2 y | 21.8 | 16.7-27.4 | 32.7 | 25.7-39.8 |
| 3 y | 23.2 | 17.8-29.1 | 39.4 | 31.4-47.2 |
| 4 y | 24.1 | 18.5-30.2 | 41.7 | 32.8-50.3 |
| PFS | ||||
| 1 y | 59.4 | 52.8-65.5 | 67.5 | 60.2-73.8 |
| 2 y | 49.5 | 42.8-55.9 | 54.3 | 46.5-61.4 |
| 3 y | 42.8 | 35.9-49.6 | 45.9 | 37.7-53.8 |
| 4 y | 40.2 | 33.2-47.2 | 41.1 | 31.4-50.5 |
| OS | ||||
| 1 y | 71.5 | 65.2-76.8 | 82.2 | 75.9-87.0 |
| 2 y | 58.7 | 51.9-64.8 | 71.8 | 64.5-77.9 |
| 3 y | 50.2 | 43.1-56.8 | 66.3 | 58.2-73.2 |
| 4 y | 47.1 | 39.9-54.0 | 60.5 | 50.6-69.1 |