Table 3. Univariate and multivariate... | American Society of Hematology

Table 3.

Univariate and multivariate analyses of factors associated with OS in MCL

	Univariate		Multivariate
	HR (95% CI)	P value	HR (95% CI)	P value
Patient characteristics
Male sex	0.92 (0.52-1.6)	.77
Age ≥ 60	1.5 (0.87-2.5)	.15
Disease characteristics
Chronic MCL (no C-findings)	0.34 (0.12-0.94)	.04	0.91 (0.19-4.3)	.90
Secondary MCL	1.0 (0.57-1.8)	.95
Diagnosis of MCL-AHN	1.9 (1.1-3.2)	.02	5.22 (1.9-14.2)	.001
Tryptase ≥ 200 ug/L	1.1 (0.45-2.5)	.88
Any PB MCs	3.9 (1.6-9.4)	.003	1.71 (0.42-7.0)	.46
Percent MCs on BM aspirate smear (continuous variable)	1.0 (0.99-1.0)	.93
Abnormal karyotype	2.5 (1.1-5.7)	.03	3.56 (1.21-14.9)	.02
KIT D816V-positive∗	0.27 (0.13-0.53)	<.001	0.43 (0.16-0.96)	.04
S/A/R mutations present†	5.8 (1.9-17.0)	.002
Treatment characteristics
First-line midostaurin	0.61 (0.34-1.1)	.09
Ever-treatment with midostaurin	0.49 (0.28-0.86)	.01	0.45 (0.07-0.63)	.002

	Univariate		Multivariate
	HR (95% CI)	P value	HR (95% CI)	P value
Patient characteristics
Male sex	0.92 (0.52-1.6)	.77
Age ≥ 60	1.5 (0.87-2.5)	.15
Disease characteristics
Chronic MCL (no C-findings)	0.34 (0.12-0.94)	.04	0.91 (0.19-4.3)	.90
Secondary MCL	1.0 (0.57-1.8)	.95
Diagnosis of MCL-AHN	1.9 (1.1-3.2)	.02	5.22 (1.9-14.2)	.001
Tryptase ≥ 200 ug/L	1.1 (0.45-2.5)	.88
Any PB MCs	3.9 (1.6-9.4)	.003	1.71 (0.42-7.0)	.46
Percent MCs on BM aspirate smear (continuous variable)	1.0 (0.99-1.0)	.93
Abnormal karyotype	2.5 (1.1-5.7)	.03	3.56 (1.21-14.9)	.02
KIT D816V-positive∗	0.27 (0.13-0.53)	<.001	0.43 (0.16-0.96)	.04
S/A/R mutations present†	5.8 (1.9-17.0)	.002
Treatment characteristics
First-line midostaurin	0.61 (0.34-1.1)	.09
Ever-treatment with midostaurin	0.49 (0.28-0.86)	.01	0.45 (0.07-0.63)	.002

Bolded patient characteristics indicate statistical significance in either univariate or multivariate analysis.

From PB or BM.

Not included in multivariate analysis because of low number of evaluable patients.