Top 10 increased proteins in lysates of resting ERp5 knockout platelets
| . | Protein . | Name . | Log FC . | Average expression . | P . | Adjusted P . | Function . | Intracellular location . |
|---|---|---|---|---|---|---|---|---|
| 1 | Nucb2 | Nucleobindin-2 | 2.0 | 27.6 | 0 | .0002 | Ca2+ binding | ER cytoplasm |
| 2 | Hspa5 | 78 kilodalton glucose-regulated protein | 1.2 | 34.8 | 0 | .0002 | ER chaperone | ER |
| 3 | Dnajc3 | DnaJ homolog subfamily C member 3 | 1.5 | 29.7 | 0 | .0004 | Unfolded protein response, inhibition of phosphorylation of eIF2a | ER |
| 4 | Hsp90b1 | Endoplasmin | 1.0 | 34.1 | 0 | .0004 | ER chaperone, transport of secreted proteins | ER |
| 5 | Pdia4 (ERp72) | Protein disulfide isomerase A4 | 1.2 | 31.4 | 0 | .0005 | Disulfide isomerase | ER |
| 6 | Hyou1 | Hypoxia upregulated protein 1 | 1.0 | 31.7 | 0 | .0013 | Hypoxia upregulated, ER stress | ER |
| 7 | Pdia3 (ERp57) | Protein disulfide isomerase A3 | 0.8 | 34.3 | 0 | .0016 | Disulfide isomerase | ER |
| 8 | Manf | Mesencephalic astrocyte–derived neurotrophic factor | 1.1 | 30.9 | 0 | .0057 | Hypoxia upregulated, ER stress | ER |
| 9 | Copg1 | Coatomer subunit gamma-1 | 0.9 | 28.4 | 0 | .0063 | Protein transport from the ER to Golgi vesicles | Cytoplasm |
| 10 | Sdf2l1 | Stromal cell-derived factor 2-like protein 1 | 1.2 | 29.2 | 0 | .0066 | Chaperone cofactor | ER |
| . | Protein . | Name . | Log FC . | Average expression . | P . | Adjusted P . | Function . | Intracellular location . |
|---|---|---|---|---|---|---|---|---|
| 1 | Nucb2 | Nucleobindin-2 | 2.0 | 27.6 | 0 | .0002 | Ca2+ binding | ER cytoplasm |
| 2 | Hspa5 | 78 kilodalton glucose-regulated protein | 1.2 | 34.8 | 0 | .0002 | ER chaperone | ER |
| 3 | Dnajc3 | DnaJ homolog subfamily C member 3 | 1.5 | 29.7 | 0 | .0004 | Unfolded protein response, inhibition of phosphorylation of eIF2a | ER |
| 4 | Hsp90b1 | Endoplasmin | 1.0 | 34.1 | 0 | .0004 | ER chaperone, transport of secreted proteins | ER |
| 5 | Pdia4 (ERp72) | Protein disulfide isomerase A4 | 1.2 | 31.4 | 0 | .0005 | Disulfide isomerase | ER |
| 6 | Hyou1 | Hypoxia upregulated protein 1 | 1.0 | 31.7 | 0 | .0013 | Hypoxia upregulated, ER stress | ER |
| 7 | Pdia3 (ERp57) | Protein disulfide isomerase A3 | 0.8 | 34.3 | 0 | .0016 | Disulfide isomerase | ER |
| 8 | Manf | Mesencephalic astrocyte–derived neurotrophic factor | 1.1 | 30.9 | 0 | .0057 | Hypoxia upregulated, ER stress | ER |
| 9 | Copg1 | Coatomer subunit gamma-1 | 0.9 | 28.4 | 0 | .0063 | Protein transport from the ER to Golgi vesicles | Cytoplasm |
| 10 | Sdf2l1 | Stromal cell-derived factor 2-like protein 1 | 1.2 | 29.2 | 0 | .0066 | Chaperone cofactor | ER |
Protein function data have been sourced from UniProt.
Log FC, log fold change.