NPM1 and FLT3 co-mutational statuses at AML diagnosis
| . | Biomarker cohort∗ (N = 469) . | ||
|---|---|---|---|
| Oral-AZA (n = 236) . | Placebo (n = 233) . | All patients (N = 469) . | |
| Gene mutation, n (%) | |||
| NPM1mut | 66 (28.0) | 71 (30.5) | 137 (29.2) |
| FLT3mut | 30 (12.7) | 36 (15.5) | 66 (14.1) |
| FLT3-ITD+ | 21 (8.9) | 25 (10.7) | 46 (9.8) |
| FLT3-TKDmut | 11 (4.7) | 13 (5.6) | 24 (5.1) |
| FLT3-ITD+ and FLT3-TKDmut | 2 (0.8) | 2 (0.9) | 4 (0.9) |
| NPM1/FLT3-ITD co-mutation status, n (%) | |||
| NPM1mut + FLT3-ITD+ | 12 (5.1) | 18 (7.7) | 30 (6.4) |
| NPM1mut + FLT3-ITD– | 54 (22.9) | 53 (22.7) | 107 (22.8) |
| NPM1wt + FLT3-ITD+ | 9 (3.8) | 7 (3.0) | 16 (3.4) |
| NPM1wt + FLT3-ITD– | 161 (68.2) | 155 (66.5) | 316 (67.4) |
| NPM1/FLT3-TKD co-mutation status, n (%) | |||
| NPM1mut + FLT3-TKDmut | 9 (3.8) | 8 (3.4) | 17 (3.6) |
| NPM1mut + FLT3-TKDwt | 57 (24.2) | 63 (27.0) | 120 (25.6) |
| NPM1wt + FLT3-TKDmut | 2 (0.8) | 5 (2.1) | 7 (1.5) |
| NPM1wt + FLT3-TKDwt | 168 (71.2) | 157 (67.4) | 325 (69.3) |
| . | Biomarker cohort∗ (N = 469) . | ||
|---|---|---|---|
| Oral-AZA (n = 236) . | Placebo (n = 233) . | All patients (N = 469) . | |
| Gene mutation, n (%) | |||
| NPM1mut | 66 (28.0) | 71 (30.5) | 137 (29.2) |
| FLT3mut | 30 (12.7) | 36 (15.5) | 66 (14.1) |
| FLT3-ITD+ | 21 (8.9) | 25 (10.7) | 46 (9.8) |
| FLT3-TKDmut | 11 (4.7) | 13 (5.6) | 24 (5.1) |
| FLT3-ITD+ and FLT3-TKDmut | 2 (0.8) | 2 (0.9) | 4 (0.9) |
| NPM1/FLT3-ITD co-mutation status, n (%) | |||
| NPM1mut + FLT3-ITD+ | 12 (5.1) | 18 (7.7) | 30 (6.4) |
| NPM1mut + FLT3-ITD– | 54 (22.9) | 53 (22.7) | 107 (22.8) |
| NPM1wt + FLT3-ITD+ | 9 (3.8) | 7 (3.0) | 16 (3.4) |
| NPM1wt + FLT3-ITD– | 161 (68.2) | 155 (66.5) | 316 (67.4) |
| NPM1/FLT3-TKD co-mutation status, n (%) | |||
| NPM1mut + FLT3-TKDmut | 9 (3.8) | 8 (3.4) | 17 (3.6) |
| NPM1mut + FLT3-TKDwt | 57 (24.2) | 63 (27.0) | 120 (25.6) |
| NPM1wt + FLT3-TKDmut | 2 (0.8) | 5 (2.1) | 7 (1.5) |
| NPM1wt + FLT3-TKDwt | 168 (71.2) | 157 (67.4) | 325 (69.3) |
Patients with available mutation data at diagnosis on electronic case report forms.