Univariate Cox regression model estimates
| Variable . | Comparisons . | OS . | PFS . | ||
|---|---|---|---|---|---|
| HR (CI 95%) . | Wald P value . | HR (CI 95%) . | Wald P value . | ||
| Cohort | BBB vs ibrutinib | 2.46 (1.24-4.90) | .010 | 2.29 (1.21-4.36) | .011 |
| Additional IT chemotherapy | No vs yes | 0.86 (0.44-1.68) | .653 | 0.93 (0.49-1.77) | .832 |
| Age at CNS relapse | 3rd vs 1st quartile | 1.05 (0.68-1.61) | .836 | 1.11 (0.73-1.68) | .631 |
| Sex | Female vs male | 0.84 (0.41-1.73) | .629 | 0.88 (0.44-1.76) | .720 |
| Morphology variant | Blastoid vs classic | 2.38 (1.14-4.98) | .005 | 2.47 (1.18-5.20) | .010 |
| Pleomorphic vs classic | 4.85 (1.61-14.57) | 3.77 (1.32-10.79) | |||
| MIPI | Intermediate vs low | 0.47 (0.16-1.41) | .401 | 0.43 (0.14-1.32) | .273 |
| High vs low | 0.69 (0.27-1.71) | 0.79 (0.32-1.95) | |||
| CNS involvement pattern | Both vs leptomeningeal | 1.31 (0.61-2.82) | .602 | 1.25 (0.59-2.64) | .844 |
| Parenchyma vs leptomeningeal | 0.77 (0.29-2.11) | 1.13 (0.47-2.73) | |||
| Extra CNS involvement | No vs yes | 1.15 (0.53-2.47) | .730 | 1.45 (0.69-3.06) | .326 |
| CNS POD ≤24 mo | Yes vs no | 2.37 (1.18-4.77) | .015 | 2.31 (1.20-4.44) | .012 |
| Variable . | Comparisons . | OS . | PFS . | ||
|---|---|---|---|---|---|
| HR (CI 95%) . | Wald P value . | HR (CI 95%) . | Wald P value . | ||
| Cohort | BBB vs ibrutinib | 2.46 (1.24-4.90) | .010 | 2.29 (1.21-4.36) | .011 |
| Additional IT chemotherapy | No vs yes | 0.86 (0.44-1.68) | .653 | 0.93 (0.49-1.77) | .832 |
| Age at CNS relapse | 3rd vs 1st quartile | 1.05 (0.68-1.61) | .836 | 1.11 (0.73-1.68) | .631 |
| Sex | Female vs male | 0.84 (0.41-1.73) | .629 | 0.88 (0.44-1.76) | .720 |
| Morphology variant | Blastoid vs classic | 2.38 (1.14-4.98) | .005 | 2.47 (1.18-5.20) | .010 |
| Pleomorphic vs classic | 4.85 (1.61-14.57) | 3.77 (1.32-10.79) | |||
| MIPI | Intermediate vs low | 0.47 (0.16-1.41) | .401 | 0.43 (0.14-1.32) | .273 |
| High vs low | 0.69 (0.27-1.71) | 0.79 (0.32-1.95) | |||
| CNS involvement pattern | Both vs leptomeningeal | 1.31 (0.61-2.82) | .602 | 1.25 (0.59-2.64) | .844 |
| Parenchyma vs leptomeningeal | 0.77 (0.29-2.11) | 1.13 (0.47-2.73) | |||
| Extra CNS involvement | No vs yes | 1.15 (0.53-2.47) | .730 | 1.45 (0.69-3.06) | .326 |
| CNS POD ≤24 mo | Yes vs no | 2.37 (1.18-4.77) | .015 | 2.31 (1.20-4.44) | .012 |