Table 2.

Univariable and multivariable analysis of factors associated with all-cause mortality and severe COVID-19 in patients with monoclonal gammopathy of undetermined significance (MGUS) and COVID-19

Dependent variablesVariables significant on univariable analysisUnivariable analysisMultivariable analysis
Risk ratio (95% CI)PRisk ratio (95% CI)P
Mortality Aged ≥65 y at COVID diagnosis 11.8 (1.6, 87.9) .016 9 (1.2, 68.9) .035 
 Cardiac disease 2.6 (1.2, 6) .02 1.9 (0.8, 4.4) .15 
 eGFR < 60 2.2 (1, 4.6) .048 1.8 (0.8, 4) .13 
Severe
COVID-19 		Aged ≥65 y at COVID diagnosis 3.5 (1.6, 7.8) .002 3.2 (1.3, 7.5) .009 
 Unvaccinated 4 (1.2, 13.5) .025 4 (1.1, 13.7) .03 
 Cardiac disease 2 (1.1, 3.4) .015 1.5 (0.8, 2.9) .17 
 Pulmonary disease 2.5 (1.5, 4.4) .001 2.1 (1.2, 3.7) .014 
 Hypertension 1.9 (1, 3.4) .041 0.2 (1.5, 0.8, 2.9) .23 
 BMI ≥ 40 kg/m2 3.4 (1.4, 8.6) .009 1.5 (0.8, 2.9) .018 
 Immunoparesis 3.2 (1.1, 9.7) .037 3.6 (1.1, 11.1) .029 
Dependent variablesVariables significant on univariable analysisUnivariable analysisMultivariable analysis
Risk ratio (95% CI)PRisk ratio (95% CI)P
Mortality Aged ≥65 y at COVID diagnosis 11.8 (1.6, 87.9) .016 9 (1.2, 68.9) .035 
 Cardiac disease 2.6 (1.2, 6) .02 1.9 (0.8, 4.4) .15 
 eGFR < 60 2.2 (1, 4.6) .048 1.8 (0.8, 4) .13 
Severe
COVID-19 		Aged ≥65 y at COVID diagnosis 3.5 (1.6, 7.8) .002 3.2 (1.3, 7.5) .009 
 Unvaccinated 4 (1.2, 13.5) .025 4 (1.1, 13.7) .03 
 Cardiac disease 2 (1.1, 3.4) .015 1.5 (0.8, 2.9) .17 
 Pulmonary disease 2.5 (1.5, 4.4) .001 2.1 (1.2, 3.7) .014 
 Hypertension 1.9 (1, 3.4) .041 0.2 (1.5, 0.8, 2.9) .23 
 BMI ≥ 40 kg/m2 3.4 (1.4, 8.6) .009 1.5 (0.8, 2.9) .018 
 Immunoparesis 3.2 (1.1, 9.7) .037 3.6 (1.1, 11.1) .029 

Boldface indicates statistical significance.

BMI, body mass index; CI, confidence interval; eGFR, estimated glomerular filtration rate.

View Large
Close Modal
This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal