Risk factors for SNs
. | PTLD (N = 145) . | AL/MDS (N = 23) . | STs (N = 65) . | |||
---|---|---|---|---|---|---|
n . | % . | n . | % . | n . | % . | |
ATG | 114 | 79 | 12 | 52 | 31 | 48 |
Alemtuzumab | 3 | 1 | 3 | 13 | 1 | 2 |
≥2/6 HLA mismatches | 58 | 40 | 12 | 52 | 27 | 42 |
aGVHD II-IV | 38 | 26 | 6 | 26 | 24 | 37 |
cGVHD | 48 | 33 | 3 | 13 | 26 | 40 |
TBI | 65 | 45 | 10 | 43 | 43 | 66 |
2-8 Gys | 36 | 7 | 27 | |||
10-14 Gys | 29 | 3 | 16 | |||
Previous autoHCT | 25 | 17 | 4 | 17 | 12 | 18 |
Previous alloHCT | 10 | 7 | 1 | 4 | 1 | 2 |
New alloHCT after UCBT | 16 | 4 | 12 | 52 | 2 | 3 |
Previous therapy lines ≥ 2 | 81 | 56 | 15 | 65 | 48 | 74 |
Conditioning regimen | ||||||
RIC | 60 | 41 | 11 | 48 | 36 | 55 |
No alkylating agent | 10 | 7 | 0 | 0 | 3 | 4 |
One alkylating agent | 72 | 50 | 14 | 61 | 44 | 68 |
Two alkylating agents | 59 | 41 | 8 | 35 | 18 | 28 |
Three alkylating agents | 4 | 2 | 1 | 4 | 0 | 0 |
Fludarabine | 99 | 68 | 15 | 65 | 50 | 77 |
. | PTLD (N = 145) . | AL/MDS (N = 23) . | STs (N = 65) . | |||
---|---|---|---|---|---|---|
n . | % . | n . | % . | n . | % . | |
ATG | 114 | 79 | 12 | 52 | 31 | 48 |
Alemtuzumab | 3 | 1 | 3 | 13 | 1 | 2 |
≥2/6 HLA mismatches | 58 | 40 | 12 | 52 | 27 | 42 |
aGVHD II-IV | 38 | 26 | 6 | 26 | 24 | 37 |
cGVHD | 48 | 33 | 3 | 13 | 26 | 40 |
TBI | 65 | 45 | 10 | 43 | 43 | 66 |
2-8 Gys | 36 | 7 | 27 | |||
10-14 Gys | 29 | 3 | 16 | |||
Previous autoHCT | 25 | 17 | 4 | 17 | 12 | 18 |
Previous alloHCT | 10 | 7 | 1 | 4 | 1 | 2 |
New alloHCT after UCBT | 16 | 4 | 12 | 52 | 2 | 3 |
Previous therapy lines ≥ 2 | 81 | 56 | 15 | 65 | 48 | 74 |
Conditioning regimen | ||||||
RIC | 60 | 41 | 11 | 48 | 36 | 55 |
No alkylating agent | 10 | 7 | 0 | 0 | 3 | 4 |
One alkylating agent | 72 | 50 | 14 | 61 | 44 | 68 |
Two alkylating agents | 59 | 41 | 8 | 35 | 18 | 28 |
Three alkylating agents | 4 | 2 | 1 | 4 | 0 | 0 |
Fludarabine | 99 | 68 | 15 | 65 | 50 | 77 |