Baseline characteristics according to the presence of bleeding complication
| . | Bleeding complication, N (%)∗ . | No bleeding complication, N (%) . | P . |
|---|---|---|---|
| 33 | 219 | ||
| Obstetrical | 26 (78.8) | 180 (82.2) | .6 |
| Nonobstetrical | 7 (21.2) | 39 (17.8) | |
| Age ± standard deviation, y | 37.9 (26-49) | 36.1 (25-47) | .4 |
| Female | 28 (84.8) | 207 (94.5) | .06 |
| Ethnicity | .5 | ||
| Ashkenazi Jewish | 22 (66.7) | 154 (70.3) | |
| Hispanic | 4 (12.1) | 11 (5.0) | |
| African American | 0 | 3 (1.4) | |
| Other White | 3 (9.1) | 20 (9.1) | |
| Other non-White | 2 (6.1) | 6 (2.7) | |
| Unknown | 2 (6.1) | 25 (11.4) | |
| Blood group | .6 | ||
| A | 17 (51.5) | 82 (38.1) | |
| B | 8 (24.2) | 45 (20.9) | |
| AB | 2 (6.1) | 13 (6.0) | |
| O | 6 (18.2) | 75 (34.9) | |
| Genotype | .08 | ||
| c.403G>T p.E135X (type II) | 6 (18.2) | 51 (23.3) | |
| c.901T>C p.F301L (type III) | 7 (21.2) | 54 (24.7) | |
| Other genotype | 4 (12.1) | 13 (5.9) | |
| Unknown | 16 (48.5) | 101 (46.1) | |
| Personal history of bleeding | <.001 | ||
| 1 type† | 14 (42.4) | 34 (15.5) | |
| ≥2 types | 2 (6.3) | 7 (3.4) | |
| Family history of bleeding | 3 (9.4) | 14 (7.0) | .6 |
| . | Bleeding complication, N (%)∗ . | No bleeding complication, N (%) . | P . |
|---|---|---|---|
| 33 | 219 | ||
| Obstetrical | 26 (78.8) | 180 (82.2) | .6 |
| Nonobstetrical | 7 (21.2) | 39 (17.8) | |
| Age ± standard deviation, y | 37.9 (26-49) | 36.1 (25-47) | .4 |
| Female | 28 (84.8) | 207 (94.5) | .06 |
| Ethnicity | .5 | ||
| Ashkenazi Jewish | 22 (66.7) | 154 (70.3) | |
| Hispanic | 4 (12.1) | 11 (5.0) | |
| African American | 0 | 3 (1.4) | |
| Other White | 3 (9.1) | 20 (9.1) | |
| Other non-White | 2 (6.1) | 6 (2.7) | |
| Unknown | 2 (6.1) | 25 (11.4) | |
| Blood group | .6 | ||
| A | 17 (51.5) | 82 (38.1) | |
| B | 8 (24.2) | 45 (20.9) | |
| AB | 2 (6.1) | 13 (6.0) | |
| O | 6 (18.2) | 75 (34.9) | |
| Genotype | .08 | ||
| c.403G>T p.E135X (type II) | 6 (18.2) | 51 (23.3) | |
| c.901T>C p.F301L (type III) | 7 (21.2) | 54 (24.7) | |
| Other genotype | 4 (12.1) | 13 (5.9) | |
| Unknown | 16 (48.5) | 101 (46.1) | |
| Personal history of bleeding | <.001 | ||
| 1 type† | 14 (42.4) | 34 (15.5) | |
| ≥2 types | 2 (6.3) | 7 (3.4) | |
| Family history of bleeding | 3 (9.4) | 14 (7.0) | .6 |
Data are presented as count (percentage) or mean ± standard deviation.
Bleeding complication defined as acute bleeding or nonprophylactic transfusion of RBCs, FFP, or TXA.
Types of bleeding include heavy menstrual bleeding, dental bleeding, easy bruising, epistaxis, obstetrical bleeding, or postoperative bleeding.