Gene mutations more frequent (OR >1) or less frequent (OR <1) in patients with DE lymphoma vs non-DE lymphoma∗
| Gene . | DE, n . | Non-DE, n . | P value . | OR . | 95% CI . | ||
|---|---|---|---|---|---|---|---|
| WT . | Mut . | WT . | Mut . | ||||
| MYD88L265P | 176 | 46 | 428 | 51 | .0006 | 2.1907 | 1.38-3.47 |
| CD79A | 212 | 10 | 468 | 11 | .1505 | 2.0047 | 0.75-5.29 |
| MYC | 198 | 24 | 450 | 29 | .0316 | 1.8791 | 1.02-3.44 |
| ERBB4 | 213 | 9 | 468 | 11 | .2238 | 1.7960 | 0.65-4.85 |
| SYK | 208 | 14 | 461 | 18 | .1718 | 1.7224 | 0.78-3.74 |
| PIM1 | 152 | 70 | 378 | 101 | .0034 | 1.7222 | 1.18-2.50 |
| MET | 203 | 19 | 453 | 26 | .1357 | 1.6295 | 0.83-3.14 |
| TRAF3 | 212 | 10 | 465 | 14 | .2745 | 1.5657 | 0.61-3.86 |
| TRAF4 | 211 | 11 | 463 | 16 | .2987 | 1.5077 | 0.62-3.53 |
| WHSC1 | 198 | 24 | 442 | 37 | .1953 | 1.4472 | 0.81-2.56 |
| CD79B | 175 | 47 | 395 | 84 | .2536 | 1.2625 | 0.83-1.91 |
| KMT2D | 142 | 80 | 330 | 149 | .1957 | 1.2473 | 0.88-1.77 |
| TNFAIP3 | 193 | 29 | 396 | 83 | .1834 | 0.7172 | 0.44-1.15 |
| EP300 | 192 | 30 | 388 | 91 | .0855 | 0.6666 | 0.41-1.06 |
| NOTCH1_N | 202 | 20 | 416 | 63 | .1317 | 0.6542 | 0.36-1.13 |
| MYD88_nonL265P | 208 | 14 | 432 | 47 | .1498 | 0.6190 | 0.31-1.18 |
| STAT3 | 210 | 12 | 430 | 49 | .0429 | 0.5019 | 0.24-0.98 |
| CARD11_nonCC | 217 | 5 | 457 | 22 | .2039 | 0.4791 | 0.14-1.32 |
| PLCG2 | 212 | 10 | 436 | 43 | .0450 | 0.4787 | 0.21-0.99 |
| TRAF2 | 218 | 4 | 461 | 18 | .2435 | 0.4704 | 0.11-1.45 |
| TXK | 216 | 6 | 452 | 27 | .1235 | 0.4655 | 0.15-1.17 |
| ITK | 219 | 3 | 463 | 16 | .2091 | 0.3968 | 0.07-1.41 |
| TRAF5 | 219 | 3 | 463 | 16 | .2091 | 0.3968 | 0.07-1.41 |
| BTK | 217 | 5 | 452 | 27 | .0515 | 0.3862 | 0.11-1.04 |
| VRK2 | 218 | 4 | 457 | 22 | .0851 | 0.3816 | 0.09-1.14 |
| CSK | 218 | 4 | 456 | 23 | .0589 | 0.3642 | 0.09-1.08 |
| NFKB2 | 217 | 5 | 450 | 29 | .0360 | 0.3580 | 0.11-0.95 |
| CYLD | 217 | 5 | 447 | 32 | .0170 | 0.3223 | 0.10-0.85 |
| MDM2 | 219 | 3 | 459 | 20 | .0662 | 0.3148 | 0.06-1.08 |
| NFKBIA | 219 | 3 | 457 | 22 | .0297 | 0.2849 | 0.05-0.96 |
| BCL10 | 218 | 4 | 448 | 31 | .0081 | 0.2655 | 0.07-0.76 |
| Gene . | DE, n . | Non-DE, n . | P value . | OR . | 95% CI . | ||
|---|---|---|---|---|---|---|---|
| WT . | Mut . | WT . | Mut . | ||||
| MYD88L265P | 176 | 46 | 428 | 51 | .0006 | 2.1907 | 1.38-3.47 |
| CD79A | 212 | 10 | 468 | 11 | .1505 | 2.0047 | 0.75-5.29 |
| MYC | 198 | 24 | 450 | 29 | .0316 | 1.8791 | 1.02-3.44 |
| ERBB4 | 213 | 9 | 468 | 11 | .2238 | 1.7960 | 0.65-4.85 |
| SYK | 208 | 14 | 461 | 18 | .1718 | 1.7224 | 0.78-3.74 |
| PIM1 | 152 | 70 | 378 | 101 | .0034 | 1.7222 | 1.18-2.50 |
| MET | 203 | 19 | 453 | 26 | .1357 | 1.6295 | 0.83-3.14 |
| TRAF3 | 212 | 10 | 465 | 14 | .2745 | 1.5657 | 0.61-3.86 |
| TRAF4 | 211 | 11 | 463 | 16 | .2987 | 1.5077 | 0.62-3.53 |
| WHSC1 | 198 | 24 | 442 | 37 | .1953 | 1.4472 | 0.81-2.56 |
| CD79B | 175 | 47 | 395 | 84 | .2536 | 1.2625 | 0.83-1.91 |
| KMT2D | 142 | 80 | 330 | 149 | .1957 | 1.2473 | 0.88-1.77 |
| TNFAIP3 | 193 | 29 | 396 | 83 | .1834 | 0.7172 | 0.44-1.15 |
| EP300 | 192 | 30 | 388 | 91 | .0855 | 0.6666 | 0.41-1.06 |
| NOTCH1_N | 202 | 20 | 416 | 63 | .1317 | 0.6542 | 0.36-1.13 |
| MYD88_nonL265P | 208 | 14 | 432 | 47 | .1498 | 0.6190 | 0.31-1.18 |
| STAT3 | 210 | 12 | 430 | 49 | .0429 | 0.5019 | 0.24-0.98 |
| CARD11_nonCC | 217 | 5 | 457 | 22 | .2039 | 0.4791 | 0.14-1.32 |
| PLCG2 | 212 | 10 | 436 | 43 | .0450 | 0.4787 | 0.21-0.99 |
| TRAF2 | 218 | 4 | 461 | 18 | .2435 | 0.4704 | 0.11-1.45 |
| TXK | 216 | 6 | 452 | 27 | .1235 | 0.4655 | 0.15-1.17 |
| ITK | 219 | 3 | 463 | 16 | .2091 | 0.3968 | 0.07-1.41 |
| TRAF5 | 219 | 3 | 463 | 16 | .2091 | 0.3968 | 0.07-1.41 |
| BTK | 217 | 5 | 452 | 27 | .0515 | 0.3862 | 0.11-1.04 |
| VRK2 | 218 | 4 | 457 | 22 | .0851 | 0.3816 | 0.09-1.14 |
| CSK | 218 | 4 | 456 | 23 | .0589 | 0.3642 | 0.09-1.08 |
| NFKB2 | 217 | 5 | 450 | 29 | .0360 | 0.3580 | 0.11-0.95 |
| CYLD | 217 | 5 | 447 | 32 | .0170 | 0.3223 | 0.10-0.85 |
| MDM2 | 219 | 3 | 459 | 20 | .0662 | 0.3148 | 0.06-1.08 |
| NFKBIA | 219 | 3 | 457 | 22 | .0297 | 0.2849 | 0.05-0.96 |
| BCL10 | 218 | 4 | 448 | 31 | .0081 | 0.2655 | 0.07-0.76 |
mut, mutated; WT, wild-type.
List of genes for which P < .3.