Table 1.

Stemness markers and used functional stem-cell assays

Murine markersNormal vs diseaseHuman markersPatient-derived xenograftSingle-cell RNA sequencingReferences
Lin/LSK     41-46  
Lin/LSK    47  
LSK-SLAM     38,48-56  
LSK-SLAM    57-59  
LSK-SLAM    60-63  
LSK-SLAM   64-67  
LSK-SLAM  CD34+/CD38+CD38   34,57,68-73  
LSK-SLAM    74,75  
  CD34+/CD38+CD38   33,76-78  
  CD34+/CD38+CD38  37,39,79-82  
  CD34+/CD38+CD38  13  
    83-91  
   92,93  
  ROS-low +/clinical trial  40,94-97  
  NKG2D  36  
Murine markersNormal vs diseaseHuman markersPatient-derived xenograftSingle-cell RNA sequencingReferences
Lin/LSK     41-46  
Lin/LSK    47  
LSK-SLAM     38,48-56  
LSK-SLAM    57-59  
LSK-SLAM    60-63  
LSK-SLAM   64-67  
LSK-SLAM  CD34+/CD38+CD38   34,57,68-73  
LSK-SLAM    74,75  
  CD34+/CD38+CD38   33,76-78  
  CD34+/CD38+CD38  37,39,79-82  
  CD34+/CD38+CD38  13  
    83-91  
   92,93  
  ROS-low +/clinical trial  40,94-97  
  NKG2D  36  

“Murine markers” refer to markers used to characterize stem cells in murine models. Murine studies were examined in the effect of gene knockout in both normal and disease contexts. “Human markers” refer to markers used to characterize stem cells in human cells. A ‘+’ in patient-derived xenograft column indicates if a patient-derived xenograft model was used in the given study. A ‘+’ in single-cell RNA sequencing indicates if single-cell RNA sequencing was used in the given study.

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