Incremental economic and clinical outcomes for the alloimmunized vs non-alloimmunized SCD, thalassemia, and anemia subpopulations: results from the multivariate analysis
| Outcome . | Measure . | Overall population . | SCD . | Thalassemia . | Anemia . |
|---|---|---|---|---|---|
| Incremental cost | Incremental median $ [95% CI] | $3211 [3170; 3252] | $2834 [2440; 3229] | $3539 [2224; 4837] | $4547 [4449; 4647] |
| P value | P < .0001 | P < .0001 | P < .0001 | P < .0001 | |
| Proportional increase in length of hospital stay | IRR [95% CI] | 1.42 [1.42; 1.43] | 1.28 [1.23; 1.33] | 1.61 [1.47; 1.77] | 1.39 [1.38; 1.40] |
| P value | P < .0001 | P < .0001 | P < .0001 | P < .0001 | |
| Risk of ICU stay | 1.79 [1.77; 1.81] | 1.60 [1.31; 1.96] | 1.45 [1.10; 1.91] | 1.57 [1.55; 1.59] | |
| P < .0001 | P < .0001 | 0.01 | P < .0001 | ||
| Proportional increase in length of ICU stay | 2.14 [2.11; 2.17] | 1.59 [1.22; 2.06] | 3.14 [2.19; 4.51] | 1.80 [1.77; 1.83] | |
| P < .0001 | P < .001 | P < .0001 | P < .0001 | ||
| Risk of death | OR [95% CI] | 1.79 [1.75; 1.83] | 1.10 [0.64; 1.90] | 1.62 [0.77; 3.43] | 1.58 [1.54; 1.62] |
| P value | P < .0001 | P = .73 | P = .21 | P < .0001 |
| Outcome . | Measure . | Overall population . | SCD . | Thalassemia . | Anemia . |
|---|---|---|---|---|---|
| Incremental cost | Incremental median $ [95% CI] | $3211 [3170; 3252] | $2834 [2440; 3229] | $3539 [2224; 4837] | $4547 [4449; 4647] |
| P value | P < .0001 | P < .0001 | P < .0001 | P < .0001 | |
| Proportional increase in length of hospital stay | IRR [95% CI] | 1.42 [1.42; 1.43] | 1.28 [1.23; 1.33] | 1.61 [1.47; 1.77] | 1.39 [1.38; 1.40] |
| P value | P < .0001 | P < .0001 | P < .0001 | P < .0001 | |
| Risk of ICU stay | 1.79 [1.77; 1.81] | 1.60 [1.31; 1.96] | 1.45 [1.10; 1.91] | 1.57 [1.55; 1.59] | |
| P < .0001 | P < .0001 | 0.01 | P < .0001 | ||
| Proportional increase in length of ICU stay | 2.14 [2.11; 2.17] | 1.59 [1.22; 2.06] | 3.14 [2.19; 4.51] | 1.80 [1.77; 1.83] | |
| P < .0001 | P < .001 | P < .0001 | P < .0001 | ||
| Risk of death | OR [95% CI] | 1.79 [1.75; 1.83] | 1.10 [0.64; 1.90] | 1.62 [0.77; 3.43] | 1.58 [1.54; 1.62] |
| P value | P < .0001 | P = .73 | P = .21 | P < .0001 |
CI, confidence interval; IRR, incidence rate ratio; OR, odds ratio.