Notable toxicities after CD19-CAR T cell infusion∗
| Adverse event . | Total . | Dose level 1 . | Dose level 2 . |
|---|---|---|---|
| CRS | |||
| Any grade | 6 | 3 | 3 |
| Grade 3-4 | 2 | 0 | 2 |
| NTX | |||
| Any Grade | 3 | 2 | 1 |
| Grade 3-4 | 1 | 0 | 1 |
| carHLH | 2 | 1 | 1 |
| Infection | Total | ||
| Bacteremia | 2 | ||
| Clostridioides difficile | 1 | ||
| Viremia | 2 | ||
| Invasive fungal | 0 | ||
| Other nonmetabolic or hematologic† | |||
| Acute kidney injury | 1 | ||
| Hepatitis | 1 | ||
| Nausea/vomiting/anorexia | 5 | ||
| Pain | 1 | ||
| Headache | 1 | ||
| Ejection fraction decreased | 1 | ||
| Hypertension | 2 | ||
| Hypotension (without fever) | 1 | ||
| Any Grade 5 | 0 | ||
| Adverse event . | Total . | Dose level 1 . | Dose level 2 . |
|---|---|---|---|
| CRS | |||
| Any grade | 6 | 3 | 3 |
| Grade 3-4 | 2 | 0 | 2 |
| NTX | |||
| Any Grade | 3 | 2 | 1 |
| Grade 3-4 | 1 | 0 | 1 |
| carHLH | 2 | 1 | 1 |
| Infection | Total | ||
| Bacteremia | 2 | ||
| Clostridioides difficile | 1 | ||
| Viremia | 2 | ||
| Invasive fungal | 0 | ||
| Other nonmetabolic or hematologic† | |||
| Acute kidney injury | 1 | ||
| Hepatitis | 1 | ||
| Nausea/vomiting/anorexia | 5 | ||
| Pain | 1 | ||
| Headache | 1 | ||
| Ejection fraction decreased | 1 | ||
| Hypertension | 2 | ||
| Hypotension (without fever) | 1 | ||
| Any Grade 5 | 0 | ||