Characteristics of iTTP cases after mRNA COVID-19 vaccines reported in VAERS
| Variable . | All cases (N = 37) . | Certainty of diagnosis of iTTP . | ||
|---|---|---|---|---|
| Definite (n = 16) . | Probable (n = 8) . | Possible (n = 13) . | ||
| Age, median (IQR), y (n = 32) | 49.5 (25.5-63.0) | 60.5 (26.0-69.0) | 52.5 (26.8-68.0) | 37.0 (25.3-60.8) |
| Females | 19 (51.4) | 3 (18.8) | 7 (87.5) | 9 (69.2) |
| Males | 17 (45.9) | 13 (81.3) | 1 (12.5) | 3 (23.1) |
| Type of vaccine | ||||
| Pfizer | 18 (48.6) | 7 (43.8) | 4 (50.0) | 7 (53.8) |
| Moderna | 15 (40.5) | 7 (43.8) | 4 (50.0) | 4 (30.8) |
| Johnson & Johnson | 4 (10.9) | 2 (12.5) | 0 (0.0) | 2 (15.4) |
| Vaccine dose | ||||
| First dose | 15 (40.5) | 6 (37.5) | 3 (37.5) | 6 (46.2) |
| Second dose | 18 (48.7) | 9 (56.3) | 3 (37.5) | 6 (46.2) |
| Third dose | 1 (2.7) | 0 (0.0) | 1 (12.5) | 0 (0.0) |
| Not reported | 3 (8.1) | 1 (6.3) | 1 (12.5) | 1 (7.7) |
| Time since vaccination, median (IQR), d (n = 32) | 13.5 (3.3-27.8) | 12.5 (3.8-35.7) | 8.5 (0.25-25.0) | 22.0 (5.8-45.5) |
| De novo iTTP | 32 (86.5) | 15 (93.8) | 5 (62.5) | 12 (92.3) |
| Recurrent iTTP | 5 (13.5) | 1 (6.2) | 3 (37.5) | 1 (7.7) |
| Variable . | All cases (N = 37) . | Certainty of diagnosis of iTTP . | ||
|---|---|---|---|---|
| Definite (n = 16) . | Probable (n = 8) . | Possible (n = 13) . | ||
| Age, median (IQR), y (n = 32) | 49.5 (25.5-63.0) | 60.5 (26.0-69.0) | 52.5 (26.8-68.0) | 37.0 (25.3-60.8) |
| Females | 19 (51.4) | 3 (18.8) | 7 (87.5) | 9 (69.2) |
| Males | 17 (45.9) | 13 (81.3) | 1 (12.5) | 3 (23.1) |
| Type of vaccine | ||||
| Pfizer | 18 (48.6) | 7 (43.8) | 4 (50.0) | 7 (53.8) |
| Moderna | 15 (40.5) | 7 (43.8) | 4 (50.0) | 4 (30.8) |
| Johnson & Johnson | 4 (10.9) | 2 (12.5) | 0 (0.0) | 2 (15.4) |
| Vaccine dose | ||||
| First dose | 15 (40.5) | 6 (37.5) | 3 (37.5) | 6 (46.2) |
| Second dose | 18 (48.7) | 9 (56.3) | 3 (37.5) | 6 (46.2) |
| Third dose | 1 (2.7) | 0 (0.0) | 1 (12.5) | 0 (0.0) |
| Not reported | 3 (8.1) | 1 (6.3) | 1 (12.5) | 1 (7.7) |
| Time since vaccination, median (IQR), d (n = 32) | 13.5 (3.3-27.8) | 12.5 (3.8-35.7) | 8.5 (0.25-25.0) | 22.0 (5.8-45.5) |
| De novo iTTP | 32 (86.5) | 15 (93.8) | 5 (62.5) | 12 (92.3) |
| Recurrent iTTP | 5 (13.5) | 1 (6.2) | 3 (37.5) | 1 (7.7) |