Survival stratified by baseline undernutrition measures categorized as not undernourished (greater than or equal to —1 z score) or undernourished (less than —1 z score) of the SPRING trial participants (n = 431) in the therapy (n = 220) and comparison groups (n = 211)
| Nutrition characteristics . | Therapy group (n = 220) . | Comparison group (n = 211) . | Combined population (n = 431) . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Survived (n = 205) . | Died (n = 15) . | P value∗ . | Survived (n = 202) . | Died (n = 9) . | P value∗ . | Survived (n = 407) . | Died (n = 24) . | P value∗ . | |
| Underweight | .226 | .360 | .035 | ||||||
| No (weight-for-age z score ≥−1) | 27 (100.0) | 0 (0.0) | 33 (100.0) | 0 (0.0) | 60 (100.0) | 0 (0.0) | |||
| Yes (weight-for-age z score <−1) | 178 (92.2) | 15 (7.8) | 169 (94.9) | 9 (5.1) | 347 (93.5) | 24 (6.5) | |||
| Stunting | .779 | .733 | 1.000 | ||||||
| No (height-for-age z score ≥−1) | 67 (94.4) | 4 (5.6) | 76 (95.0) | 4 (5.0) | 143 (94.7) | 8 (5.3) | |||
| Yes (height-for-age z score <−1) | 138 (92.6) | 11 (7.4) | 126 (96.2) | 5 (3.8) | 264 (94.3) | 16 (5.7) | |||
| Wasting | .554 | .689 | 1.000 | ||||||
| No (BMI z score ≥−1) | 54 (91.5) | 5 (8.5) | 49 (98.0) | 1 (2.0) | 103 (94.5) | 6 (5.5) | |||
| Yes (BMI z score <−1) | 151 (93.8) | 10 (6.2) | 153 (95.0) | 8 (5.0) | 304 (94.4) | 18 (5.6) | |||
| Nutrition characteristics . | Therapy group (n = 220) . | Comparison group (n = 211) . | Combined population (n = 431) . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Survived (n = 205) . | Died (n = 15) . | P value∗ . | Survived (n = 202) . | Died (n = 9) . | P value∗ . | Survived (n = 407) . | Died (n = 24) . | P value∗ . | |
| Underweight | .226 | .360 | .035 | ||||||
| No (weight-for-age z score ≥−1) | 27 (100.0) | 0 (0.0) | 33 (100.0) | 0 (0.0) | 60 (100.0) | 0 (0.0) | |||
| Yes (weight-for-age z score <−1) | 178 (92.2) | 15 (7.8) | 169 (94.9) | 9 (5.1) | 347 (93.5) | 24 (6.5) | |||
| Stunting | .779 | .733 | 1.000 | ||||||
| No (height-for-age z score ≥−1) | 67 (94.4) | 4 (5.6) | 76 (95.0) | 4 (5.0) | 143 (94.7) | 8 (5.3) | |||
| Yes (height-for-age z score <−1) | 138 (92.6) | 11 (7.4) | 126 (96.2) | 5 (3.8) | 264 (94.3) | 16 (5.7) | |||
| Wasting | .554 | .689 | 1.000 | ||||||
| No (BMI z score ≥−1) | 54 (91.5) | 5 (8.5) | 49 (98.0) | 1 (2.0) | 103 (94.5) | 6 (5.5) | |||
| Yes (BMI z score <−1) | 151 (93.8) | 10 (6.2) | 153 (95.0) | 8 (5.0) | 304 (94.4) | 18 (5.6) | |||
The therapy group comprised of children with abnormal transcranial Doppler velocities on hydroxyurea therapy, and the comparison group was children with nonelevated transcranial Doppler velocities.
Fisher exact test.