Table 4. Baseline nutritional status z... | American Society of Hematology

Table 4.

Baseline nutritional status z scores and risk of death

Model	Variable	Therapy			Comparison			Combined population
Model	Variable	HR	95% CI	P value	HR	95% CI	P value	HR	95% CI	P value
Model 1: weight-for-age z score	Age	0.912	0.700-1.118	.494	0.912	0.677-1.156	.546	0.886	0.729-1.076	.222
	Female	1.244	0.431-3.592	.687	0.839	0.215-3.266	.800	1.151	0.514-2.578	.733
	Hemoglobin (g/dL)	1.343	0.679-2.656	.396	0.595	0.704-2.714	.190	0.873	0.546-1.396	.570
	Weight-for-age z score	0.593	0.300-0.956	.032	0.610	0.321-1.158	.131	0.580	0.399-0.843	.004
Model 2: height-for-age z score	Age	0.929	0.713-1.211	.586	0.976	0.719-1.323	.875	0.916	0.756-1.111	.373
	Female	1.450	0.509-4.133	.487	0.669	0.178-2.507	.551	1.108	0.495-2.479	.804
	Hemoglobin (g/dL)	1.275	0.640-2.543	.490	0.563	0.253-1.248	.157	0.864	0.535-1.396	.551
	Height-for-age z score	0.692	0.446-1.074	.101	0.950	0.547-1.650	.855	0.753	0.541-1.047	.092
Model 3: BMI z score	Age	0.992	0.770-1.277	.950	0.943	0.712-1.250	.684	0.936	0.777-1.128	.489
	Female	1.364	0.475-3.912	.564	0.970	0.238-3.963	.966	1.128	0.503-2.530	.771
	Hemoglobin (g/dL)	1.322	0.680-2.569	.411	0.582	0.272-1.245	.163	0.840	0.527-1.339	.464
	BMI z score	0.891	0.569-1.396	.615	0.629	0.386-1.026	.063	0.778	0.568-1.065	.117

Model	Variable	Therapy			Comparison			Combined population
Model	Variable	HR	95% CI	P value	HR	95% CI	P value	HR	95% CI	P value
Model 1: weight-for-age z score	Age	0.912	0.700-1.118	.494	0.912	0.677-1.156	.546	0.886	0.729-1.076	.222
	Female	1.244	0.431-3.592	.687	0.839	0.215-3.266	.800	1.151	0.514-2.578	.733
	Hemoglobin (g/dL)	1.343	0.679-2.656	.396	0.595	0.704-2.714	.190	0.873	0.546-1.396	.570
	Weight-for-age z score	0.593	0.300-0.956	.032	0.610	0.321-1.158	.131	0.580	0.399-0.843	.004
Model 2: height-for-age z score	Age	0.929	0.713-1.211	.586	0.976	0.719-1.323	.875	0.916	0.756-1.111	.373
	Female	1.450	0.509-4.133	.487	0.669	0.178-2.507	.551	1.108	0.495-2.479	.804
	Hemoglobin (g/dL)	1.275	0.640-2.543	.490	0.563	0.253-1.248	.157	0.864	0.535-1.396	.551
	Height-for-age z score	0.692	0.446-1.074	.101	0.950	0.547-1.650	.855	0.753	0.541-1.047	.092
Model 3: BMI z score	Age	0.992	0.770-1.277	.950	0.943	0.712-1.250	.684	0.936	0.777-1.128	.489
	Female	1.364	0.475-3.912	.564	0.970	0.238-3.963	.966	1.128	0.503-2.530	.771
	Hemoglobin (g/dL)	1.322	0.680-2.569	.411	0.582	0.272-1.245	.163	0.840	0.527-1.339	.464
	BMI z score	0.891	0.569-1.396	.615	0.629	0.386-1.026	.063	0.778	0.568-1.065	.117

Multivariate Cox regression of factors associated with death among children with SCA in the SPRING Trial (n = 431). Separate models for height-for-age, weight-for-age, and BMI z scores.

Multivariate Cox regression models included age, sex, and hemoglobin at screening. The therapy group comprised children with abnormal transcranial Doppler velocities on hydroxyurea therapy, and the comparison group was children with nonelevated transcranial Doppler velocities.

Nutritional status is classified into weight-for-age, height-for-age, and BMI z scores using the WHO growth references.

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