Table 3.

Treatment characteristics of patients treated with and without MoAbs

Non-MoAb (N = 50)
N (%)		MoAb (N = 14)
N (%)		P value
Sex    
Male 28 (56.0) 10 (71.4) .299 
Female 22 (44.0) 4 (28.6)  
Age, median (IQR) 57 (50-67) 54 (47-67) .409 
Diagnosis    
Diffuse large B-cell lymphoma 39 (78.0) 10 (71.4)  
High-grade B-cell lymphoma with MYC and BCL2/BCL6 1 (2.0) 1 (7.1)  
Primary mediastinal B-cell lymphoma 3 (6.0) 1 (7.1)  
Transformed follicular lymphoma 1 (2.0) 1 (7.1) .516 
Mantle cell lymphoma 1 (2.0) 1 (7.1)  
Follicular lymphoma 3 (6.0) 0 (0)  
B-ALL 2 (4.0) 0 (0)  
Number of previous lines of therapy, median (IQR) 3 (3-4) 3 (3-4) .719 
Previous auto HSCT 14 (28.0) 2 (14.3) .487 
Time since auto HSCT, days median (IQR) 428 (255-892) 1221 (734-1707) .267 
CAR T-cell product   .472 
Axicabtagene ciloleucel 23 (46.0) 9 (64.3)  
Lisocabtagene maraleucel 1 (2.0) 0 (0)  
Tisagenlecleucel 23 (46.0) 4 (28.6)  
Other 2 (4.0) 0 (0)  
Unknown 1 (2.0) 1 (7.1)  
CAR T-cell therapy conditioning    
Fludarabine/cyclophosphamide 47 (94.0) 14 (100.0) 1.000 
Bendamustine 1 (2.0) 0 (0)  
Other 1 (2.0) 0 (0)  
Unknown 1 (2.0) 0 (0)  
Time since CAR T-cell infusion, days median (IQR) 162 (65-420) 358 (126-730) .028 
Variant of SARS-CoV-2 infection    
Wild-type 7 (14.0) 0 (0.0)  
Alpha mutation 2 (4.0) 1 (7.1) .046 
Delta mutation 2 (4.0) 2 (14.3)  
Omicron mutation 11 (22.0) 7 (50.0)  
Unknown 28 (56.0) 4 (28.6)  
Number of vaccinations    
0 34 (68.0) 2 (14.3) <.001 
1 2 (4.0) 1 (7.1)  
2 11 (22.0) 7 (50.0)  
3 0 (0.0) 3 (21.4)  
4 3 (6.0) 1 (7.1)  
Comorbidities∗     
Not present 19 (38.0) 6 (42.9) 1.000 
1 comorbidity 17 (34.0) 5 (35.7)  
2 comorbidities 8 (16.0) 2 (14.3)  
≥ 3 comorbidities 6 (12.0) 1 (7.1)  
Leukocyte count (cells per mm3) at COVID-19 diagnosis, median (IQR) 2670 (1720-4200) 2350 (2150-2950) .786 
Lymphocyte count (cells per mm3) at COVID-19 diagnosis, median (IQR) 500 (230-1000) 400 (270-700) .931 
Neutrophil count (cells per mm3) at COVID-19 diagnosis, median (IQR) 1250 (570-2620) 1740 (1245-2045) .470 
Severity of infection    
At home 10 (20.0) 4 (28.6) .493 
Admitted to the hospital 40 (80.0) 10 (71.4) .493 
Admitted to the ICU 15 (30.0) 3 (21.4) .659 
Treatment with MoAbs 0 (0.0) 14 (100.0) <.001 
Type of MoAb    
Bamlanivimab/etesevimab 0 (0.0) 1 (7.1)  
Casirivimab/imdevimab 0 (0.0) 3 (21.4) <.001 
Sotrovimab 0 (0.0) 10 (71.4)  
Treatment with convalescent plasma 13 (26.0) 3 (21.4) .725 
Treatment with viral replication inhibitor 14 (28.0) 4 (28.6) .966 
Treatment with steroids 24 (48.0) 6 (42.9) .733 
Treatment with tocilizumab 5 (10.0) 1 (7.1) .746 
Outcome    
Alive 31 (62.0) 12 (85.7) .095 
Dead 19 (38.0) 2 (14.3)  
Cause of death    
COVID-19 or contributed by COVID-19 16 (32.0) 0 (0.0) .015 
Hematological malignancy 3 (6.0) 2 (14.0) .476 
Non-MoAb (N = 50)
N (%)		MoAb (N = 14)
N (%)		P value
Sex    
Male 28 (56.0) 10 (71.4) .299 
Female 22 (44.0) 4 (28.6)  
Age, median (IQR) 57 (50-67) 54 (47-67) .409 
Diagnosis    
Diffuse large B-cell lymphoma 39 (78.0) 10 (71.4)  
High-grade B-cell lymphoma with MYC and BCL2/BCL6 1 (2.0) 1 (7.1)  
Primary mediastinal B-cell lymphoma 3 (6.0) 1 (7.1)  
Transformed follicular lymphoma 1 (2.0) 1 (7.1) .516 
Mantle cell lymphoma 1 (2.0) 1 (7.1)  
Follicular lymphoma 3 (6.0) 0 (0)  
B-ALL 2 (4.0) 0 (0)  
Number of previous lines of therapy, median (IQR) 3 (3-4) 3 (3-4) .719 
Previous auto HSCT 14 (28.0) 2 (14.3) .487 
Time since auto HSCT, days median (IQR) 428 (255-892) 1221 (734-1707) .267 
CAR T-cell product   .472 
Axicabtagene ciloleucel 23 (46.0) 9 (64.3)  
Lisocabtagene maraleucel 1 (2.0) 0 (0)  
Tisagenlecleucel 23 (46.0) 4 (28.6)  
Other 2 (4.0) 0 (0)  
Unknown 1 (2.0) 1 (7.1)  
CAR T-cell therapy conditioning    
Fludarabine/cyclophosphamide 47 (94.0) 14 (100.0) 1.000 
Bendamustine 1 (2.0) 0 (0)  
Other 1 (2.0) 0 (0)  
Unknown 1 (2.0) 0 (0)  
Time since CAR T-cell infusion, days median (IQR) 162 (65-420) 358 (126-730) .028 
Variant of SARS-CoV-2 infection    
Wild-type 7 (14.0) 0 (0.0)  
Alpha mutation 2 (4.0) 1 (7.1) .046 
Delta mutation 2 (4.0) 2 (14.3)  
Omicron mutation 11 (22.0) 7 (50.0)  
Unknown 28 (56.0) 4 (28.6)  
Number of vaccinations    
0 34 (68.0) 2 (14.3) <.001 
1 2 (4.0) 1 (7.1)  
2 11 (22.0) 7 (50.0)  
3 0 (0.0) 3 (21.4)  
4 3 (6.0) 1 (7.1)  
Comorbidities∗     
Not present 19 (38.0) 6 (42.9) 1.000 
1 comorbidity 17 (34.0) 5 (35.7)  
2 comorbidities 8 (16.0) 2 (14.3)  
≥ 3 comorbidities 6 (12.0) 1 (7.1)  
Leukocyte count (cells per mm3) at COVID-19 diagnosis, median (IQR) 2670 (1720-4200) 2350 (2150-2950) .786 
Lymphocyte count (cells per mm3) at COVID-19 diagnosis, median (IQR) 500 (230-1000) 400 (270-700) .931 
Neutrophil count (cells per mm3) at COVID-19 diagnosis, median (IQR) 1250 (570-2620) 1740 (1245-2045) .470 
Severity of infection    
At home 10 (20.0) 4 (28.6) .493 
Admitted to the hospital 40 (80.0) 10 (71.4) .493 
Admitted to the ICU 15 (30.0) 3 (21.4) .659 
Treatment with MoAbs 0 (0.0) 14 (100.0) <.001 
Type of MoAb    
Bamlanivimab/etesevimab 0 (0.0) 1 (7.1)  
Casirivimab/imdevimab 0 (0.0) 3 (21.4) <.001 
Sotrovimab 0 (0.0) 10 (71.4)  
Treatment with convalescent plasma 13 (26.0) 3 (21.4) .725 
Treatment with viral replication inhibitor 14 (28.0) 4 (28.6) .966 
Treatment with steroids 24 (48.0) 6 (42.9) .733 
Treatment with tocilizumab 5 (10.0) 1 (7.1) .746 
Outcome    
Alive 31 (62.0) 12 (85.7) .095 
Dead 19 (38.0) 2 (14.3)  
Cause of death    
COVID-19 or contributed by COVID-19 16 (32.0) 0 (0.0) .015 
Hematological malignancy 3 (6.0) 2 (14.0) .476 

ALL, acute lymphoid leukemia; auto HSCT, autologous HSCT.

∗

One or more comorbidities present (chronic cardiomyopathy, chronic pulmonary disease, diabetes, liver disease, obesity, renal impairment, smoker).

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