Demographics
| Characteristic . | Treated patients (n = 38), n (%) . |
|---|---|
| Age (y) | |
| Median | 66.5 (40-78) |
| Range | |
| Male | 23 (60.5) |
| ECOG PS | |
| 0 | 18 (47.4) |
| 1 | 17 (44.7) |
| 2 | 3 (7.9) |
| Rai stage | |
| 0 | 0 |
| I | 3 (7.9) |
| II | 19 (50.0) |
| III | 11 (28.9) |
| IV | 5 (13.2) |
| β2 microglobulin (mg/L) | |
| Median | 3.7 (2, 11.4) |
| Range | |
| Hemoglobin | |
| Median | 11.9 (7.8, 15.4) |
| Range | |
| Platelet count | |
| Median | 138 (69, 438) |
| Range | |
| Cytogenetics | |
| Del (17p) | 5 (13.2) |
| Del (11q) | 6 (15.8) |
| Trisomy 12 | 6 (15.8) |
| Del (13q) | 15 (39.5) |
| No cytogenetic abnormalities | 6 (15.8) |
| IGHV mutation status | |
| Mutated | 15 (39.5) |
| Unmutated | 23 (60.5) |
| Mutated TP53 | |
| Yes | 8 (21.1) |
| No | 30 (78.9) |
| Mutated NOTCH1 | |
| Yes | 9 (23.7) |
| No | 29 (76.3) |
| Mutated SF3B1 | |
| Yes | 4 (10.5) |
| No | 34 (89.5) |
| At least 1 high-risk feature (TP53mut/del(17p)/del(11q)/ NOTCH1 mut/IGHV unmutated) | |
| Yes | 26 (68.4) |
| No | 12 (31.6) |
| Characteristic . | Treated patients (n = 38), n (%) . |
|---|---|
| Age (y) | |
| Median | 66.5 (40-78) |
| Range | |
| Male | 23 (60.5) |
| ECOG PS | |
| 0 | 18 (47.4) |
| 1 | 17 (44.7) |
| 2 | 3 (7.9) |
| Rai stage | |
| 0 | 0 |
| I | 3 (7.9) |
| II | 19 (50.0) |
| III | 11 (28.9) |
| IV | 5 (13.2) |
| β2 microglobulin (mg/L) | |
| Median | 3.7 (2, 11.4) |
| Range | |
| Hemoglobin | |
| Median | 11.9 (7.8, 15.4) |
| Range | |
| Platelet count | |
| Median | 138 (69, 438) |
| Range | |
| Cytogenetics | |
| Del (17p) | 5 (13.2) |
| Del (11q) | 6 (15.8) |
| Trisomy 12 | 6 (15.8) |
| Del (13q) | 15 (39.5) |
| No cytogenetic abnormalities | 6 (15.8) |
| IGHV mutation status | |
| Mutated | 15 (39.5) |
| Unmutated | 23 (60.5) |
| Mutated TP53 | |
| Yes | 8 (21.1) |
| No | 30 (78.9) |
| Mutated NOTCH1 | |
| Yes | 9 (23.7) |
| No | 29 (76.3) |
| Mutated SF3B1 | |
| Yes | 4 (10.5) |
| No | 34 (89.5) |
| At least 1 high-risk feature (TP53mut/del(17p)/del(11q)/ NOTCH1 mut/IGHV unmutated) | |
| Yes | 26 (68.4) |
| No | 12 (31.6) |
Cytogenetics are reported via Döhner hierarchical method.17
ECOG, Eastern Cooperative Oncology Group; PS, performance status.