Characteristics of 40 486 patients with NHL based on TRES score
. | All patients . | TRES score . | P . | ||||||
---|---|---|---|---|---|---|---|---|---|
0 . | 1 . | 2-3 . | |||||||
N . | (%) . | N . | (%) . | N . | (%) . | N . | (%) . | ||
Subtype | |||||||||
CLL | 11 406 | 28.2 | 5038 | 30.5 | 4141 | 27.7 | 2227 | 24.8 | < .0001 |
Cutaneous T-cell lymphoma | 1051 | 2.6 | 494 | 3.0 | 378 | 2.5 | 179 | 2.0 | |
DLBCL | 11 154 | 27.6 | 4139 | 25.0 | 4144 | 27.7 | 2871 | 32.0 | |
FL | 5087 | 12.6 | 2247 | 13.6 | 1901 | 12.7 | 939 | 10.5 | |
Lymphoplasmacytic lymphoma | 651 | 1.6 | 294 | 1.8 | 227 | 1.5 | 130 | 1.4 | |
Mantle cell lymphoma | 1565 | 3.9 | 655 | 4.0 | 571 | 3.8 | 339 | 3.8 | |
Marginal zone lymphoma | 3647 | 9.0 | 1533 | 9.3 | 1360 | 9.1 | 754 | 8.4 | |
Peripheral T-cell lymphoma | 1136 | 2.8 | 420 | 2.5 | 446 | 3.0 | 270 | 3.0 | |
Other | 4789 | 11.8 | 1706 | 10.3 | 1808 | 12.1 | 1275 | 14.2 | |
Year of diagnosis | |||||||||
2008 | 2977 | 7.4 | 1297 | 43.5 | 1121 | 37.6 | 559 | 18.7 | < .0001 |
2009 | 3127 | 7.7 | 1312 | 41.9 | 1162 | 37.1 | 653 | 20.8 | |
2010 | 3198 | 7.9 | 1314 | 41.0 | 1224 | 38.2 | 660 | 20.6 | |
2011 | 3163 | 7.8 | 1307 | 41.3 | 1175 | 37.1 | 681 | 21.5 | |
2012 | 3482 | 8.6 | 1378 | 39.5 | 1335 | 38.3 | 769 | 22.0 | |
2013 | 3917 | 9.7 | 1550 | 39.5 | 1429 | 36.4 | 938 | 23.9 | |
2014 | 4996 | 12.3 | 2041 | 40.8 | 1840 | 36.8 | 1115 | 22.3 | |
2015 | 5155 | 12.7 | 2103 | 40.7 | 1870 | 36.2 | 1182 | 22.9 | |
2016 | 5264 | 13.0 | 2113 | 40.1 | 1918 | 36.4 | 1233 | 23.4 | |
2017 | 5207 | 12.9 | 2111 | 40.5 | 1902 | 36.5 | 1194 | 22.9 | < .0001 |
Age at diagnosis, y | |||||||||
66-70 | 8323 | 20.6 | 4245 | 51.0 | 2699 | 32.4 | 1379 | 16.5 | |
71-75 | 9323 | 23.0 | 4206 | 45.1 | 3240 | 34.7 | 1877 | 20.1 | |
76-80 | 8741 | 21.6 | 3472 | 39.7 | 3244 | 37.1 | 2025 | 23.1 | |
81-85 | 7586 | 18.7 | 2624 | 34.5 | 3024 | 39.8 | 1938 | 25.5 | |
86+ | 6513 | 16.1 | 1979 | 30.3 | 2769 | 42.5 | 1765 | 27.0 | |
Sex | |||||||||
Female | 20041 | 49.5 | 8707 | 43.4 | 7336 | 36.6 | 3998 | 19.9 | < .0001 |
Male | 20445 | 50.5 | 7819 | 38.2 | 7640 | 37.3 | 4986 | 24.3 | |
Race and ethnicity | |||||||||
White | 36729 | 90.7 | 15001 | 40.8 | 13618 | 37.0 | 8110 | 22.0 | < .0001 |
Black | 1032 | 2.5 | 350 | 33.9 | 397 | 38.4 | 285 | 27.6 | |
Hispanic | 1343 | 3.3 | 511 | 38.0 | 490 | 36.4 | 342 | 25.4 | |
Other/unknown | 1382 | 3.4 | 664 | 48.0 | 471 | 34.0 | 247 | 17.8 | |
Marital status | |||||||||
Married | 16631 | 41.1 | 7157 | 43.0 | 6001 | 36.0 | 3473 | 20.8 | |
Not married | 20738 | 51.2 | 8014 | 38.6 | 7894 | 38.0 | 4830 | 23.2 | < .0001 |
Unknown | 3117 | 7.7 | 1355 | 43.4 | 1081 | 34.6 | 681 | 21.8 | |
Region | |||||||||
Midwest | 4440 | 11.0 | 1770 | 39.8 | 1630 | 36.7 | 1040 | 23.4 | <.0001 |
Northeast | 17082 | 42.2 | 6442 | 37.7 | 6507 | 38.0 | 4133 | 24.1 | |
South | 6728 | 16.6 | 2561 | 38.0 | 2541 | 37.7 | 1626 | 24.1 | |
West | 12236 | 30.2 | 5753 | 47.0 | 4298 | 35.1 | 2185 | 17.8 | |
Census tract median income | |||||||||
Quartile 1, $0-$48 549 | 10697 | 26.4 | 4139 | 38.6 | 4008 | 37.4 | 2550 | 23.8 | < .0001 |
Quartile 2, $48 550-$66 509 | 9945 | 24.6 | 3953 | 39.7 | 3686 | 37.0 | 2306 | 23.1 | |
Quartile 3, $66 510-$92 388 | 9915 | 24.5 | 4095 | 41.3 | 3670 | 37.0 | 2150 | 21.6 | |
Quartile 4, >$92 389 | 9929 | 24.5 | 4339 | 43.7 | 3612 | 36.3 | 1978 | 19.9 | |
Census tract, % nonhigh-school graduates | |||||||||
Quartile 1, ≥14.09% | 9914 | 24.5 | 3668 | 36.9 | 3751 | 37.8 | 2495 | 25.1 | < .0001 |
Quartile 2, 8.17%-14.08% | 9931 | 24.5 | 3800 | 38.2 | 3738 | 37.6 | 2393 | 24.0 | |
Quartile 3, 4.45%-8.16% | 9953 | 24.6 | 4182 | 42.0 | 3644 | 36.6 | 2127 | 21.3 | |
Quartile 4, 0.0%-4.44% | 10688 | 26.4 | 4876 | 45.6 | 3843 | 35.9 | 1969 | 18.4 | |
Stage | |||||||||
I | 4755 | 11.7 | 1962 | 41.2 | 1769 | 37.2 | 1024 | 21.5 | .7952 |
II | 2340 | 5.8 | 942 | 40.2 | 891 | 38.0 | 507 | 21.6 | |
III | 2728 | 6.7 | 1145 | 41.9 | 985 | 36.1 | 598 | 21.9 | |
IV | 5969 | 14.7 | 2441 | 40.8 | 2202 | 36.8 | 1326 | 22.2 | |
Unknown | 24694 | 61.0 | 10036 | 40.6 | 9129 | 36.9 | 5529 | 22.3 | |
Diagnosis of other cancer before NHL | |||||||||
No | 30938 | 76.4 | 13085 | 42.2 | 11264 | 36.4 | 6589 | 21.2 | < .0001 |
Yes | 9548 | 23.6 | 3441 | 36.0 | 3712 | 38.8 | 2395 | 25.0 | |
Diagnosis of other cancer after NHL | |||||||||
No | 36287 | 89.6 | 14598 | 40.2 | 13508 | 37.2 | 8181 | 22.5 | < .0001 |
Yes | 4199 | 10.4 | 1928 | 45.9 | 1468 | 34.9 | 803 | 19.1 | |
Initial therapy | |||||||||
None | 15604 | 38.5 | 5897 | 37.7 | 5826 | 37.3 | 3881 | 24.8 | < .0001 |
Chemotherapy | 1148 | 2.8 | 488 | 42.5 | 418 | 36.4 | 242 | 21.0 | |
Immunotherapy | 4899 | 12.1 | 2034 | 41.5 | 1852 | 37.8 | 1013 | 20.6 | |
Chemoimmunotherapy | 12341 | 30.5 | 5348 | 43.3 | 4489 | 36.3 | 2504 | 20.2 | |
Radiation therapy | 4789 | 11.8 | 1991 | 41.5 | 1757 | 36.6 | 1041 | 21.7 | |
Targeted therapy | 1705 | 4.2 | 768 | 45.0 | 634 | 37.1 | 303 | 17.7 |
. | All patients . | TRES score . | P . | ||||||
---|---|---|---|---|---|---|---|---|---|
0 . | 1 . | 2-3 . | |||||||
N . | (%) . | N . | (%) . | N . | (%) . | N . | (%) . | ||
Subtype | |||||||||
CLL | 11 406 | 28.2 | 5038 | 30.5 | 4141 | 27.7 | 2227 | 24.8 | < .0001 |
Cutaneous T-cell lymphoma | 1051 | 2.6 | 494 | 3.0 | 378 | 2.5 | 179 | 2.0 | |
DLBCL | 11 154 | 27.6 | 4139 | 25.0 | 4144 | 27.7 | 2871 | 32.0 | |
FL | 5087 | 12.6 | 2247 | 13.6 | 1901 | 12.7 | 939 | 10.5 | |
Lymphoplasmacytic lymphoma | 651 | 1.6 | 294 | 1.8 | 227 | 1.5 | 130 | 1.4 | |
Mantle cell lymphoma | 1565 | 3.9 | 655 | 4.0 | 571 | 3.8 | 339 | 3.8 | |
Marginal zone lymphoma | 3647 | 9.0 | 1533 | 9.3 | 1360 | 9.1 | 754 | 8.4 | |
Peripheral T-cell lymphoma | 1136 | 2.8 | 420 | 2.5 | 446 | 3.0 | 270 | 3.0 | |
Other | 4789 | 11.8 | 1706 | 10.3 | 1808 | 12.1 | 1275 | 14.2 | |
Year of diagnosis | |||||||||
2008 | 2977 | 7.4 | 1297 | 43.5 | 1121 | 37.6 | 559 | 18.7 | < .0001 |
2009 | 3127 | 7.7 | 1312 | 41.9 | 1162 | 37.1 | 653 | 20.8 | |
2010 | 3198 | 7.9 | 1314 | 41.0 | 1224 | 38.2 | 660 | 20.6 | |
2011 | 3163 | 7.8 | 1307 | 41.3 | 1175 | 37.1 | 681 | 21.5 | |
2012 | 3482 | 8.6 | 1378 | 39.5 | 1335 | 38.3 | 769 | 22.0 | |
2013 | 3917 | 9.7 | 1550 | 39.5 | 1429 | 36.4 | 938 | 23.9 | |
2014 | 4996 | 12.3 | 2041 | 40.8 | 1840 | 36.8 | 1115 | 22.3 | |
2015 | 5155 | 12.7 | 2103 | 40.7 | 1870 | 36.2 | 1182 | 22.9 | |
2016 | 5264 | 13.0 | 2113 | 40.1 | 1918 | 36.4 | 1233 | 23.4 | |
2017 | 5207 | 12.9 | 2111 | 40.5 | 1902 | 36.5 | 1194 | 22.9 | < .0001 |
Age at diagnosis, y | |||||||||
66-70 | 8323 | 20.6 | 4245 | 51.0 | 2699 | 32.4 | 1379 | 16.5 | |
71-75 | 9323 | 23.0 | 4206 | 45.1 | 3240 | 34.7 | 1877 | 20.1 | |
76-80 | 8741 | 21.6 | 3472 | 39.7 | 3244 | 37.1 | 2025 | 23.1 | |
81-85 | 7586 | 18.7 | 2624 | 34.5 | 3024 | 39.8 | 1938 | 25.5 | |
86+ | 6513 | 16.1 | 1979 | 30.3 | 2769 | 42.5 | 1765 | 27.0 | |
Sex | |||||||||
Female | 20041 | 49.5 | 8707 | 43.4 | 7336 | 36.6 | 3998 | 19.9 | < .0001 |
Male | 20445 | 50.5 | 7819 | 38.2 | 7640 | 37.3 | 4986 | 24.3 | |
Race and ethnicity | |||||||||
White | 36729 | 90.7 | 15001 | 40.8 | 13618 | 37.0 | 8110 | 22.0 | < .0001 |
Black | 1032 | 2.5 | 350 | 33.9 | 397 | 38.4 | 285 | 27.6 | |
Hispanic | 1343 | 3.3 | 511 | 38.0 | 490 | 36.4 | 342 | 25.4 | |
Other/unknown | 1382 | 3.4 | 664 | 48.0 | 471 | 34.0 | 247 | 17.8 | |
Marital status | |||||||||
Married | 16631 | 41.1 | 7157 | 43.0 | 6001 | 36.0 | 3473 | 20.8 | |
Not married | 20738 | 51.2 | 8014 | 38.6 | 7894 | 38.0 | 4830 | 23.2 | < .0001 |
Unknown | 3117 | 7.7 | 1355 | 43.4 | 1081 | 34.6 | 681 | 21.8 | |
Region | |||||||||
Midwest | 4440 | 11.0 | 1770 | 39.8 | 1630 | 36.7 | 1040 | 23.4 | <.0001 |
Northeast | 17082 | 42.2 | 6442 | 37.7 | 6507 | 38.0 | 4133 | 24.1 | |
South | 6728 | 16.6 | 2561 | 38.0 | 2541 | 37.7 | 1626 | 24.1 | |
West | 12236 | 30.2 | 5753 | 47.0 | 4298 | 35.1 | 2185 | 17.8 | |
Census tract median income | |||||||||
Quartile 1, $0-$48 549 | 10697 | 26.4 | 4139 | 38.6 | 4008 | 37.4 | 2550 | 23.8 | < .0001 |
Quartile 2, $48 550-$66 509 | 9945 | 24.6 | 3953 | 39.7 | 3686 | 37.0 | 2306 | 23.1 | |
Quartile 3, $66 510-$92 388 | 9915 | 24.5 | 4095 | 41.3 | 3670 | 37.0 | 2150 | 21.6 | |
Quartile 4, >$92 389 | 9929 | 24.5 | 4339 | 43.7 | 3612 | 36.3 | 1978 | 19.9 | |
Census tract, % nonhigh-school graduates | |||||||||
Quartile 1, ≥14.09% | 9914 | 24.5 | 3668 | 36.9 | 3751 | 37.8 | 2495 | 25.1 | < .0001 |
Quartile 2, 8.17%-14.08% | 9931 | 24.5 | 3800 | 38.2 | 3738 | 37.6 | 2393 | 24.0 | |
Quartile 3, 4.45%-8.16% | 9953 | 24.6 | 4182 | 42.0 | 3644 | 36.6 | 2127 | 21.3 | |
Quartile 4, 0.0%-4.44% | 10688 | 26.4 | 4876 | 45.6 | 3843 | 35.9 | 1969 | 18.4 | |
Stage | |||||||||
I | 4755 | 11.7 | 1962 | 41.2 | 1769 | 37.2 | 1024 | 21.5 | .7952 |
II | 2340 | 5.8 | 942 | 40.2 | 891 | 38.0 | 507 | 21.6 | |
III | 2728 | 6.7 | 1145 | 41.9 | 985 | 36.1 | 598 | 21.9 | |
IV | 5969 | 14.7 | 2441 | 40.8 | 2202 | 36.8 | 1326 | 22.2 | |
Unknown | 24694 | 61.0 | 10036 | 40.6 | 9129 | 36.9 | 5529 | 22.3 | |
Diagnosis of other cancer before NHL | |||||||||
No | 30938 | 76.4 | 13085 | 42.2 | 11264 | 36.4 | 6589 | 21.2 | < .0001 |
Yes | 9548 | 23.6 | 3441 | 36.0 | 3712 | 38.8 | 2395 | 25.0 | |
Diagnosis of other cancer after NHL | |||||||||
No | 36287 | 89.6 | 14598 | 40.2 | 13508 | 37.2 | 8181 | 22.5 | < .0001 |
Yes | 4199 | 10.4 | 1928 | 45.9 | 1468 | 34.9 | 803 | 19.1 | |
Initial therapy | |||||||||
None | 15604 | 38.5 | 5897 | 37.7 | 5826 | 37.3 | 3881 | 24.8 | < .0001 |
Chemotherapy | 1148 | 2.8 | 488 | 42.5 | 418 | 36.4 | 242 | 21.0 | |
Immunotherapy | 4899 | 12.1 | 2034 | 41.5 | 1852 | 37.8 | 1013 | 20.6 | |
Chemoimmunotherapy | 12341 | 30.5 | 5348 | 43.3 | 4489 | 36.3 | 2504 | 20.2 | |
Radiation therapy | 4789 | 11.8 | 1991 | 41.5 | 1757 | 36.6 | 1041 | 21.7 | |
Targeted therapy | 1705 | 4.2 | 768 | 45.0 | 634 | 37.1 | 303 | 17.7 |