Characteristics of included patients
| . | Total (n = 1195) . | GSTT157 (n = 97) . | HOVON-13016 (n = 65) . | HOVON-8415 (n = 308) . | IAEA17 (n = 104) . | NCRI18 (n = 133) . | PETAL19 (n = 368) . | SAKK20 (n = 120) . |
|---|---|---|---|---|---|---|---|---|
| Age (median, IQR) | 62 (51-70) | 61 (49-70) | 63 (54-72) | 65 (56-72) | 57 (43-65) | 61 (49-68) | 61 (51-70) | 59 (49-68) |
| >60 y | 547 (46) | 47 (48) | 30 (46) | 100 (32) | 63 (61) | 63 (47) | 179 (49) | 65 (54) |
| ≤60 y | 648 (54) | 50 (52) | 35 (54) | 208 (68) | 41 (39) | 70 (53) | 189 (51) | 55 (46) |
| Ann Arbor stage | ||||||||
| I | 108 (9) | 9 (9) | 0 | 0 | 11 (11) | 8 (6) | 66 (18) | 14 (12) |
| II | 284 (24) | 20 (21) | 7 (11) | 55 (18) | 25 (24) | 51 (38) | 80 (22) | 42 (35) |
| III | 269 (23) | 11 (11) | 8 (12) | 70 (23) | 23 (22) | 35 (26) | 75 (20) | 26 (22) |
| IV | 534 (45) | 57 (59) | 50 (77) | 183 (59) | 45 (43) | 39 (29) | 147 (40) | 38 (32) |
| WHO performance status | ||||||||
| 0 | 590 (49) | 32 (33) | 38 (58) | 175 (57) | 36 (35) | 75 (56) | 166 (45) | 68 (57) |
| 1 | 449 (38) | 35 (36) | 23 (35) | 94 (31) | 44 (42) | 44 (33) | 165 (45) | 44 (37) |
| 2 | 124 (10) | 18 (19) | 3 (5) | 39 (13) | 15 (14) | 14 (11) | 27 (7) | 8 (7) |
| 3 | 30 (3) | 12 (12) | 1 (2) | 0 | 7 (7) | 0 | 10 (3) | 0 |
| 4 | 2 | 0 | 0 | 0 | 2 (2) | 0 | 0 | 0 |
| LDH | ||||||||
| ≤ Normal | 478 (40) | 35 (36) | 16 (25) | 100 (32) | 54 (52) | 51 (38) | 154 (42) | 62 (52) |
| Normal | 713 (60) | 62 (64) | 45 (69) | 208 (68) | 50 (48) | 82 (62) | 214 (58) | 58 (48) |
| Missing | 4 | 4 (6) | ||||||
| Extranodal involvement | ||||||||
| ≥1 | 773 (65) | 47 (48) | 30 (46) | 182 (59) | 67 (64) | 106 (80) | 249 (68) | 92 (77) |
| <1 | 422 (35) | 50 (52) | 35 (54) | 126 (41) | 37 (36) | 27 (20) | 119 (32) | 28 (23) |
| IPI low | 368 (31) | 26 (27) | 9 (14) | 51 (17) | 44 (42) | 52 (39) | 125 (34) | 61 (51) |
| Low-intermediate | 264 (22) | 10 (10) | 14 (22) | 75 (24) | 16 (15) | 28 (31) | 97 (26) | 24 (20) |
| High-intermediate | 331 (28) | 30 (31) | 29 (45) | 106 (34) | 22 (21) | 35 (26) | 89 (24) | 20 (17) |
| High | 232 (19) | 31 (32) | 13 (20) | 76 (25) | 22 (21) | 18 (14) | 57 (15) | 15 (13) |
| . | Total (n = 1195) . | GSTT157 (n = 97) . | HOVON-13016 (n = 65) . | HOVON-8415 (n = 308) . | IAEA17 (n = 104) . | NCRI18 (n = 133) . | PETAL19 (n = 368) . | SAKK20 (n = 120) . |
|---|---|---|---|---|---|---|---|---|
| Age (median, IQR) | 62 (51-70) | 61 (49-70) | 63 (54-72) | 65 (56-72) | 57 (43-65) | 61 (49-68) | 61 (51-70) | 59 (49-68) |
| >60 y | 547 (46) | 47 (48) | 30 (46) | 100 (32) | 63 (61) | 63 (47) | 179 (49) | 65 (54) |
| ≤60 y | 648 (54) | 50 (52) | 35 (54) | 208 (68) | 41 (39) | 70 (53) | 189 (51) | 55 (46) |
| Ann Arbor stage | ||||||||
| I | 108 (9) | 9 (9) | 0 | 0 | 11 (11) | 8 (6) | 66 (18) | 14 (12) |
| II | 284 (24) | 20 (21) | 7 (11) | 55 (18) | 25 (24) | 51 (38) | 80 (22) | 42 (35) |
| III | 269 (23) | 11 (11) | 8 (12) | 70 (23) | 23 (22) | 35 (26) | 75 (20) | 26 (22) |
| IV | 534 (45) | 57 (59) | 50 (77) | 183 (59) | 45 (43) | 39 (29) | 147 (40) | 38 (32) |
| WHO performance status | ||||||||
| 0 | 590 (49) | 32 (33) | 38 (58) | 175 (57) | 36 (35) | 75 (56) | 166 (45) | 68 (57) |
| 1 | 449 (38) | 35 (36) | 23 (35) | 94 (31) | 44 (42) | 44 (33) | 165 (45) | 44 (37) |
| 2 | 124 (10) | 18 (19) | 3 (5) | 39 (13) | 15 (14) | 14 (11) | 27 (7) | 8 (7) |
| 3 | 30 (3) | 12 (12) | 1 (2) | 0 | 7 (7) | 0 | 10 (3) | 0 |
| 4 | 2 | 0 | 0 | 0 | 2 (2) | 0 | 0 | 0 |
| LDH | ||||||||
| ≤ Normal | 478 (40) | 35 (36) | 16 (25) | 100 (32) | 54 (52) | 51 (38) | 154 (42) | 62 (52) |
| Normal | 713 (60) | 62 (64) | 45 (69) | 208 (68) | 50 (48) | 82 (62) | 214 (58) | 58 (48) |
| Missing | 4 | 4 (6) | ||||||
| Extranodal involvement | ||||||||
| ≥1 | 773 (65) | 47 (48) | 30 (46) | 182 (59) | 67 (64) | 106 (80) | 249 (68) | 92 (77) |
| <1 | 422 (35) | 50 (52) | 35 (54) | 126 (41) | 37 (36) | 27 (20) | 119 (32) | 28 (23) |
| IPI low | 368 (31) | 26 (27) | 9 (14) | 51 (17) | 44 (42) | 52 (39) | 125 (34) | 61 (51) |
| Low-intermediate | 264 (22) | 10 (10) | 14 (22) | 75 (24) | 16 (15) | 28 (31) | 97 (26) | 24 (20) |
| High-intermediate | 331 (28) | 30 (31) | 29 (45) | 106 (34) | 22 (21) | 35 (26) | 89 (24) | 20 (17) |
| High | 232 (19) | 31 (32) | 13 (20) | 76 (25) | 22 (21) | 18 (14) | 57 (15) | 15 (13) |
LDH, lactate dehydrogenase.