Top 10 list of MDS collaborative priority research goals
| Priority research goals . |
|---|
| 1. To establish a new standard of care for frontline higher-risk MDS |
| 2. To develop better treatment options for DNA methyltransferase inhibitor (DNMTi)-refractory MDS |
| 3. To develop effective strategies for TP53-mutated MDS |
| 4. To advance novel treatment strategies to impact the underlying pathophysiology of lower-risk MDS |
| 5. To conduct clinical trials in a collaborative international effort with emphasis on equal access and on PROs |
| 6. To formulate unified diagnostic criteria and classification subgroups for MDS |
| 7. To establish and systematically validate clinically meaningful response criteria for MDS therapy |
| 8. To establish tools to predict, and ultimately reduce, risk of progression of CH to MDS and other hematological malignancies in clinical practice |
| 9. To establish linked clinical databases and biobanks allowing sharing of data |
| 10. To improve the development and dissemination of reliable preclinical models of MDS |
| Priority research goals . |
|---|
| 1. To establish a new standard of care for frontline higher-risk MDS |
| 2. To develop better treatment options for DNA methyltransferase inhibitor (DNMTi)-refractory MDS |
| 3. To develop effective strategies for TP53-mutated MDS |
| 4. To advance novel treatment strategies to impact the underlying pathophysiology of lower-risk MDS |
| 5. To conduct clinical trials in a collaborative international effort with emphasis on equal access and on PROs |
| 6. To formulate unified diagnostic criteria and classification subgroups for MDS |
| 7. To establish and systematically validate clinically meaningful response criteria for MDS therapy |
| 8. To establish tools to predict, and ultimately reduce, risk of progression of CH to MDS and other hematological malignancies in clinical practice |
| 9. To establish linked clinical databases and biobanks allowing sharing of data |
| 10. To improve the development and dissemination of reliable preclinical models of MDS |