Table 2.

Mean age of HbSC vs HbSS patients with severe complications (standard deviation)

CharacteristicsHbSCHbSSP value 
Acute pain (≥ 3 episodes per y) only (n = 180) 32.8 (8.2) 30.5 (7.9) .071 
ACS only (n = 34) 32.7 (6.0) 31.3 (9.1) .667 
Severe symptomatic chronic anemia only (n = 4) N/A 39.8 (8.1) N/A 
Symptomatic AVN (n = 110) 34.8 (6.8) 32.8 (7.2) .141 
Cerebrovascular accident/stroke (n = 10) 36.0 (7.6) 27.9 (10.0) .247 
Priapism (n = 37) 31.8 (5.8) 28.5 (6.0) .252 
Nephropathy (n = 61) 26.9 (5.9) 31.2 (7.6) .154 
Proliferative SCD Retinopathy (n = 24) 32.7 (7.3) 22.3 (4.0) .012 
Active chronic leg ulcer (n = 53) N/A 32.7 (7.2) N/A 
Systemic hypertension (n = 30) 38.2 (6.0) 40.3 (5.1) .418 
Chronic pain (n = 266) 35.2 (7.4) 32.7 (7.2) < .001 
CharacteristicsHbSCHbSSP value 
Acute pain (≥ 3 episodes per y) only (n = 180) 32.8 (8.2) 30.5 (7.9) .071 
ACS only (n = 34) 32.7 (6.0) 31.3 (9.1) .667 
Severe symptomatic chronic anemia only (n = 4) N/A 39.8 (8.1) N/A 
Symptomatic AVN (n = 110) 34.8 (6.8) 32.8 (7.2) .141 
Cerebrovascular accident/stroke (n = 10) 36.0 (7.6) 27.9 (10.0) .247 
Priapism (n = 37) 31.8 (5.8) 28.5 (6.0) .252 
Nephropathy (n = 61) 26.9 (5.9) 31.2 (7.6) .154 
Proliferative SCD Retinopathy (n = 24) 32.7 (7.3) 22.3 (4.0) .012 
Active chronic leg ulcer (n = 53) N/A 32.7 (7.2) N/A 
Systemic hypertension (n = 30) 38.2 (6.0) 40.3 (5.1) .418 
Chronic pain (n = 266) 35.2 (7.4) 32.7 (7.2) < .001 

The causes of the chronic pain include AVN, osteoarthritis of the knee and elbow joints, spondylosis (both lumbar and cervical), and active chronic leg ulcers.

N/A, not available.

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