Characteristics of symptomatic AVN in adults with HbSC disease compared with adults with HbSS disease
| Characteristics . | HbSC (N = 49) . | HbSS (N = 61) . | P value . |
|---|---|---|---|
| Sex | .616 | ||
| Male, n (%) | 17 (34.7) | 24 (39.3) | |
| Female, n (%) | 32 (65.3) | 37 (60.7) | |
| Age, mean (standard deviation) | 34.8 (6.8) | 32.8 (7.2) | .141 |
| Number of patients with symptomatic AVN aged 30 y and above, n (%) | 39 (79.6) | 42 (68.9) | .204 |
| Symptomatic AVN of the femoral head(s), n (%) | 44 (89.8) | 55 (90.1) | .949 |
| Bilateral symptomatic AVN of the femoral heads, n (%) | 14 (28.6) | 22 (36.0) | .405 |
| Unilateral symptomatic AVN of the femoral head, n (%) | 30 (61.2) | 33 (54.1) | .453 |
| Symptomatic AVN of right femoral head, n (%)∗ | 20 (66.7) | 19 (57.6) | .292 |
| Symptomatic AVN of the humeral head(s), n (%) | 5 (10.2) | 6 (9.8) | .949 |
| Symptomatic AVN with a history of 3 or more acute pain events per y, n (%) | 11 (22.4) | 21 (34.4) | .169 |
| Characteristics . | HbSC (N = 49) . | HbSS (N = 61) . | P value . |
|---|---|---|---|
| Sex | .616 | ||
| Male, n (%) | 17 (34.7) | 24 (39.3) | |
| Female, n (%) | 32 (65.3) | 37 (60.7) | |
| Age, mean (standard deviation) | 34.8 (6.8) | 32.8 (7.2) | .141 |
| Number of patients with symptomatic AVN aged 30 y and above, n (%) | 39 (79.6) | 42 (68.9) | .204 |
| Symptomatic AVN of the femoral head(s), n (%) | 44 (89.8) | 55 (90.1) | .949 |
| Bilateral symptomatic AVN of the femoral heads, n (%) | 14 (28.6) | 22 (36.0) | .405 |
| Unilateral symptomatic AVN of the femoral head, n (%) | 30 (61.2) | 33 (54.1) | .453 |
| Symptomatic AVN of right femoral head, n (%)∗ | 20 (66.7) | 19 (57.6) | .292 |
| Symptomatic AVN of the humeral head(s), n (%) | 5 (10.2) | 6 (9.8) | .949 |
| Symptomatic AVN with a history of 3 or more acute pain events per y, n (%) | 11 (22.4) | 21 (34.4) | .169 |
The denominator for individuals with HbSC who had symptomatic AVN of the right femoral head was n = 30, whereas that for individuals with HbSS was n = 33.