Demographics based on final diagnosis (N = 1298)
| Disease group . | . | N (%) . | ||||
|---|---|---|---|---|---|---|
| MDS . | Non-MDS myeloid malignancy . | All myeloid malignancies . | No myeloid malignancy . | All . | ||
| 342 (26) . | 167 (13) . | 509 (39) . | 789 (61) . | 1298 . | ||
| MDS WHO diagnosis | MDS with single lineage dysplasia | 20 (6) | - | - | - | - |
| MDS with single lineage dysplasia and ring sideroblasts | 27 (8) | - | - | - | - | |
| MDS with multilineage dysplasia | 93 (27) | - | - | - | - | |
| MDS with multilineage dysplasia and ring sideroblasts | 56 (16) | - | - | - | - | |
| MDS with excess blasts-1 (5%-9% blasts) | 53 (15) | - | - | - | - | |
| MDS with excess blasts-2 (10%-19% blasts) | 55 (16) | - | - | - | - | |
| MDS with isolated del(5q) | 16 (5) | - | - | - | - | |
| MDS, unclassifiable | 22 (6) | - | - | - | - | |
| Undefined | 0 (0) | - | - | - | - | |
| Sex | Female | 118 (35) | 59 (35) | 177 (35) | 343 (43) | 520 (40) |
| Male | 224 (65) | 108 (65) | 332 (65) | 446 (57) | 778 (60) | |
| Age | Median (minimum-maximum) | 74.0 (30.0-95.0) | 74.0 (25.0-95.0) | 74.0 (25.0-95.0) | 71.0 (18.0-95.0) | 72.0 (18.0-95.0) |
| <50 | 9 (3) | 9 (5) | 18 (4) | 62 (8) | 80 (6) | |
| 50-59 | 26 (8) | 10 (6) | 36 (7) | 107 (14) | 143 (11) | |
| 60-69 | 73 (21) | 36 (22) | 109 (21) | 201 (25) | 310 (24) | |
| 70-79 | 152 (44) | 64 (38) | 216 (42) | 277 (35) | 493 (38) | |
| 80-89 | 70 (20) | 41 (25) | 111 (22) | 130 (16) | 241 (19) | |
| 90+ | 12 (4) | 7 (4) | 19 (4) | 12 (2) | 31 (2) | |
| Race | American Indian or Alaska Native | 2 (1) | 0 (0) | 2 (<1) | 7 (1) | 9 (1) |
| Asian | 2 (1) | 6 (4) | 8 (2) | 16 (2) | 24 (2) | |
| Native Hawaiian or other Pacific Islander | 1 (<1) | 0 (0) | 1 (<1) | 1 (<1) | 2 (<1) | |
| Black or African American | 13 (4) | 4 (2) | 17 (3) | 49 (6) | 66 (5) | |
| White | 316 (92) | 156 (93) | 472 (93) | 701 (89) | 1173 (90) | |
| Multiracial | 0 (0) | 0 (0) | 0 (0) | 3 (<1) | 3 (<1) | |
| Unknown/not reported | 8 (2) | 1 (1) | 9 (2) | 12 (2) | 21 (2) | |
| Ethnicity | Hispanic or Latino | 11 (3) | 5 (3) | 16 (3) | 21 (3) | 37 (3) |
| Not Hispanic or Latino | 320 (94) | 160 (96) | 480 (94) | 753 (95) | 1233 (95) | |
| Unknown/not reported | 11 (3) | 2 (1) | 13 (3) | 15 (2) | 28 (2) | |
| IPSS-R | Very low | 68 (20) | - | - | - | - |
| Low | 103 (30) | - | - | - | - | |
| Intermediate | 62 (18) | - | - | - | - | |
| High | 35 (10) | - | - | - | - | |
| Very high | 32 (9) | - | - | - | - | |
| Missing | 42 (12) | - | - | - | - | |
| Karyotype classification | Normal | 156 (46) | 75 (45) | 231 (45) | 483 (61) | 714 (55) |
| Abnormal | 136 (40) | 61 (37) | 197 (39) | 95 (12) | 292 (22) | |
| Undetermined (no metaphases reported) | 5 (1) | 1 (1) | 6 (1) | 24 (3) | 30 (2) | |
| Missing | 45 (13) | 30 (18) | 75 (15) | 187 (24) | 262 (20) | |
| Disease group . | . | N (%) . | ||||
|---|---|---|---|---|---|---|
| MDS . | Non-MDS myeloid malignancy . | All myeloid malignancies . | No myeloid malignancy . | All . | ||
| 342 (26) . | 167 (13) . | 509 (39) . | 789 (61) . | 1298 . | ||
| MDS WHO diagnosis | MDS with single lineage dysplasia | 20 (6) | - | - | - | - |
| MDS with single lineage dysplasia and ring sideroblasts | 27 (8) | - | - | - | - | |
| MDS with multilineage dysplasia | 93 (27) | - | - | - | - | |
| MDS with multilineage dysplasia and ring sideroblasts | 56 (16) | - | - | - | - | |
| MDS with excess blasts-1 (5%-9% blasts) | 53 (15) | - | - | - | - | |
| MDS with excess blasts-2 (10%-19% blasts) | 55 (16) | - | - | - | - | |
| MDS with isolated del(5q) | 16 (5) | - | - | - | - | |
| MDS, unclassifiable | 22 (6) | - | - | - | - | |
| Undefined | 0 (0) | - | - | - | - | |
| Sex | Female | 118 (35) | 59 (35) | 177 (35) | 343 (43) | 520 (40) |
| Male | 224 (65) | 108 (65) | 332 (65) | 446 (57) | 778 (60) | |
| Age | Median (minimum-maximum) | 74.0 (30.0-95.0) | 74.0 (25.0-95.0) | 74.0 (25.0-95.0) | 71.0 (18.0-95.0) | 72.0 (18.0-95.0) |
| <50 | 9 (3) | 9 (5) | 18 (4) | 62 (8) | 80 (6) | |
| 50-59 | 26 (8) | 10 (6) | 36 (7) | 107 (14) | 143 (11) | |
| 60-69 | 73 (21) | 36 (22) | 109 (21) | 201 (25) | 310 (24) | |
| 70-79 | 152 (44) | 64 (38) | 216 (42) | 277 (35) | 493 (38) | |
| 80-89 | 70 (20) | 41 (25) | 111 (22) | 130 (16) | 241 (19) | |
| 90+ | 12 (4) | 7 (4) | 19 (4) | 12 (2) | 31 (2) | |
| Race | American Indian or Alaska Native | 2 (1) | 0 (0) | 2 (<1) | 7 (1) | 9 (1) |
| Asian | 2 (1) | 6 (4) | 8 (2) | 16 (2) | 24 (2) | |
| Native Hawaiian or other Pacific Islander | 1 (<1) | 0 (0) | 1 (<1) | 1 (<1) | 2 (<1) | |
| Black or African American | 13 (4) | 4 (2) | 17 (3) | 49 (6) | 66 (5) | |
| White | 316 (92) | 156 (93) | 472 (93) | 701 (89) | 1173 (90) | |
| Multiracial | 0 (0) | 0 (0) | 0 (0) | 3 (<1) | 3 (<1) | |
| Unknown/not reported | 8 (2) | 1 (1) | 9 (2) | 12 (2) | 21 (2) | |
| Ethnicity | Hispanic or Latino | 11 (3) | 5 (3) | 16 (3) | 21 (3) | 37 (3) |
| Not Hispanic or Latino | 320 (94) | 160 (96) | 480 (94) | 753 (95) | 1233 (95) | |
| Unknown/not reported | 11 (3) | 2 (1) | 13 (3) | 15 (2) | 28 (2) | |
| IPSS-R | Very low | 68 (20) | - | - | - | - |
| Low | 103 (30) | - | - | - | - | |
| Intermediate | 62 (18) | - | - | - | - | |
| High | 35 (10) | - | - | - | - | |
| Very high | 32 (9) | - | - | - | - | |
| Missing | 42 (12) | - | - | - | - | |
| Karyotype classification | Normal | 156 (46) | 75 (45) | 231 (45) | 483 (61) | 714 (55) |
| Abnormal | 136 (40) | 61 (37) | 197 (39) | 95 (12) | 292 (22) | |
| Undetermined (no metaphases reported) | 5 (1) | 1 (1) | 6 (1) | 24 (3) | 30 (2) | |
| Missing | 45 (13) | 30 (18) | 75 (15) | 187 (24) | 262 (20) | |
MDS/MPN, AML with blasts less than 30%, and ICUS.
ICUS, idiopathic cytopenias of undetermined significance; IPSS-R, Revised International Prognostic Scoring System.