Table 1. List of CCR4-CARs and their... | American Society of Hematology

Table 1.

List of CCR4-CARs and their original mAbs

#	CAR	scFv	mAb clone	Affinity (Kd)	CCR4 epitope	Reference
1	KW_H2L	H to L	KW-0761	ND (slow dissociation)	NT 12 to 29 (DESIYSNYYLYESIPKPC)	¹¹
2	KW_L2H	L to H
3	1-49_H2L	H to L	mAb 1-49	77.98 nM	ND (combinatorial of NT and ECL)	²⁹
4	1-49_L2H	L to H
5	2-3_H2L	H to L	mAb 2-3	1.39 nM
6	2-3_L2H	L to H
7	h1567_H2L	H to L	h1567	2.54 nM
8	h1567_L2H	L to H

#	CAR	scFv	mAb clone	Affinity (Kd)	CCR4 epitope	Reference
1	KW_H2L	H to L	KW-0761	ND (slow dissociation)	NT 12 to 29 (DESIYSNYYLYESIPKPC)	¹¹
2	KW_L2H	L to H
3	1-49_H2L	H to L	mAb 1-49	77.98 nM	ND (combinatorial of NT and ECL)	²⁹
4	1-49_L2H	L to H
5	2-3_H2L	H to L	mAb 2-3	1.39 nM
6	2-3_L2H	L to H
7	h1567_H2L	H to L	h1567	2.54 nM
8	h1567_L2H	L to H

K_d values are from data as antibodies but not as scFvs.

ECL, extracellular loop; ND, not determined; NT, N-terminus.