Association between LSC17 status and baseline characteristics
| Characteristics . | Low LSC17 (n = 252) . | High LSC17 (n = 252) . | P value . | ||
|---|---|---|---|---|---|
| Number . | % . | Number . | % . | ||
| Sex | .21 | ||||
| Female | 111 | 44 | 126 | 50 | |
| Male | 141 | 56 | 126 | 50 | |
| Age, y | .002 | ||||
| ≥ 50 | 93 | 36 | 129 | 51 | |
| < 50 | 159 | 63 | 123 | 49 | |
| WBC count | .03 | ||||
| ≤ 20 ×109/L | 152 | 60 | 176 | 70 | |
| > 20 ×109/L | 100 | 40 | 76 | 30 | |
| ELN 2022 risk | < .0001 | ||||
| Favorable | 113 | 46 | 29 | 12 | |
| Intermediate | 70 | 28 | 82 | 33 | |
| Unfavorable | 65 | 26 | 140 | 56 | |
| Cytogenetics | |||||
| Normal | 155 | 62 | 130 | 52 | .01 |
| Complex | 15 | 6 | 36 | 14 | .003 |
| Monosomal | 7 | 3 | 25 | 10 | .001 |
| del17p or abn17p | 1 | 0 | 15 | 6 | .0004 |
| t(9;11) | 5 | 2 | 2 | 1 | .29 |
| t(v;11) | 9 | 4 | 11 | 4 | .82 |
| inv(3)/t(3;3) | 1 | 0 | 8 | 3 | .04 |
| t(6;9) | 2 | 1 | 5 | 2 | .45 |
| Mutations | |||||
| NPM1 | 121 | 48 | 66 | 26 | < .0001 |
| In-frame bZIP CEBPA | 27 | 11 | 2 | 1 | < .0001 |
| FLT3-ITD | 48 | 19 | 71 | 28 | .02 |
| FLT3-TKD | 38 | 15 | 22 | 9 | .04 |
| RUNX1 | 14 | 6 | 40 | 16 | .0003 |
| ASXL1 | 18 | 7 | 27 | 11 | .21 |
| TP53 | 9 | 4 | 21 | 8 | .04 |
| Characteristics . | Low LSC17 (n = 252) . | High LSC17 (n = 252) . | P value . | ||
|---|---|---|---|---|---|
| Number . | % . | Number . | % . | ||
| Sex | .21 | ||||
| Female | 111 | 44 | 126 | 50 | |
| Male | 141 | 56 | 126 | 50 | |
| Age, y | .002 | ||||
| ≥ 50 | 93 | 36 | 129 | 51 | |
| < 50 | 159 | 63 | 123 | 49 | |
| WBC count | .03 | ||||
| ≤ 20 ×109/L | 152 | 60 | 176 | 70 | |
| > 20 ×109/L | 100 | 40 | 76 | 30 | |
| ELN 2022 risk | < .0001 | ||||
| Favorable | 113 | 46 | 29 | 12 | |
| Intermediate | 70 | 28 | 82 | 33 | |
| Unfavorable | 65 | 26 | 140 | 56 | |
| Cytogenetics | |||||
| Normal | 155 | 62 | 130 | 52 | .01 |
| Complex | 15 | 6 | 36 | 14 | .003 |
| Monosomal | 7 | 3 | 25 | 10 | .001 |
| del17p or abn17p | 1 | 0 | 15 | 6 | .0004 |
| t(9;11) | 5 | 2 | 2 | 1 | .29 |
| t(v;11) | 9 | 4 | 11 | 4 | .82 |
| inv(3)/t(3;3) | 1 | 0 | 8 | 3 | .04 |
| t(6;9) | 2 | 1 | 5 | 2 | .45 |
| Mutations | |||||
| NPM1 | 121 | 48 | 66 | 26 | < .0001 |
| In-frame bZIP CEBPA | 27 | 11 | 2 | 1 | < .0001 |
| FLT3-ITD | 48 | 19 | 71 | 28 | .02 |
| FLT3-TKD | 38 | 15 | 22 | 9 | .04 |
| RUNX1 | 14 | 6 | 40 | 16 | .0003 |
| ASXL1 | 18 | 7 | 27 | 11 | .21 |
| TP53 | 9 | 4 | 21 | 8 | .04 |
P values from Fisher exact tests. Bold values indicate significant P < 0.05.