Characteristics of patients diagnosed with MCL at age <70 years in Sweden between 2000 and 2014 (N = 620) by selection for treatment with HD-ASCT or not within 12 months of diagnosis and among general population comparators (N = 6200)
| Variable . | Patients not treated with HD-ASCT<12 m∗ . | Patients treated with HD-ASCT<12 m . | P value . | All patients, N (column %) <70 y . | Comparators matched 1:10, birth year and sex . |
|---|---|---|---|---|---|
| Overall, N | 373 | 247 | 620 (100)† | 6 200 (100) | |
| Median age (range), y | 65 (22-69) | 58 (32-69) | 62 (22-69) | 63 (22-70) | |
| Age categories at diagnosis or matching,‡ n (%), y | |||||
| <60 | 91 (24.4) | 136 (55.1) | <.001 | 227 (36.6) | 2 140 (34.5) |
| 60-69 | 282 (75.6) | 111 (44.9) | 393 (63.4) | 4 060 (65.5) | |
| Sex, n (%) | |||||
| Male | 281 (75.3) | 192 (77.7) | .492 | 473 (76.3) | 4 730 (76.3) |
| Female | 92 (24.7) | 55 (22.3) | 147 (23.7) | 1 470 (23.7) | |
| Year of diagnosis or matching, n (%) | |||||
| 2000-2004 | 121 (32.4) | 51 (21.7) | .006 | 172 (27.7) | 1720 (27.7) |
| 2005-2009 | 104 (27.9) | 82 (33.2) | 186 (30) | 1860 (30) | |
| 2010-2014 | 148 (39.7) | 114 (46.2) | 262 (42.3) | 2620 (42.3) | |
| CCI, n (%) | |||||
| 0 | 213 (57.1) | 190 (76.9) | <.001 | 403 (65.0) | 4 669 (75.3) |
| 1 | 50 (13.4) | 22 (8.9) | 72 (11.6) | 715 (11.5) | |
| 2+ | 110 (29.5) | 35 (14.2) | 145 (23.4) | 816 (13.2) | |
| Highest achieved education level | |||||
| ≤9 years of schooling, n (%) | 113 (31) | 39 (16.2) | <.001 | 152 (25.1) | 1 782 (29.6) |
| 10-12 years of schooling, n (%) | 155 (42.5) | 124 (51.5) | 279 (46.0) | 2 567 (42.7) | |
| >12 years of schooling, n (%) | 97 (26.6) | 78 (32.4) | 175 (28.9) | 1 669 (27.7) | |
| Missing, n | 8 | 6 | 14 | 182 |
| Variable . | Patients not treated with HD-ASCT<12 m∗ . | Patients treated with HD-ASCT<12 m . | P value . | All patients, N (column %) <70 y . | Comparators matched 1:10, birth year and sex . |
|---|---|---|---|---|---|
| Overall, N | 373 | 247 | 620 (100)† | 6 200 (100) | |
| Median age (range), y | 65 (22-69) | 58 (32-69) | 62 (22-69) | 63 (22-70) | |
| Age categories at diagnosis or matching,‡ n (%), y | |||||
| <60 | 91 (24.4) | 136 (55.1) | <.001 | 227 (36.6) | 2 140 (34.5) |
| 60-69 | 282 (75.6) | 111 (44.9) | 393 (63.4) | 4 060 (65.5) | |
| Sex, n (%) | |||||
| Male | 281 (75.3) | 192 (77.7) | .492 | 473 (76.3) | 4 730 (76.3) |
| Female | 92 (24.7) | 55 (22.3) | 147 (23.7) | 1 470 (23.7) | |
| Year of diagnosis or matching, n (%) | |||||
| 2000-2004 | 121 (32.4) | 51 (21.7) | .006 | 172 (27.7) | 1720 (27.7) |
| 2005-2009 | 104 (27.9) | 82 (33.2) | 186 (30) | 1860 (30) | |
| 2010-2014 | 148 (39.7) | 114 (46.2) | 262 (42.3) | 2620 (42.3) | |
| CCI, n (%) | |||||
| 0 | 213 (57.1) | 190 (76.9) | <.001 | 403 (65.0) | 4 669 (75.3) |
| 1 | 50 (13.4) | 22 (8.9) | 72 (11.6) | 715 (11.5) | |
| 2+ | 110 (29.5) | 35 (14.2) | 145 (23.4) | 816 (13.2) | |
| Highest achieved education level | |||||
| ≤9 years of schooling, n (%) | 113 (31) | 39 (16.2) | <.001 | 152 (25.1) | 1 782 (29.6) |
| 10-12 years of schooling, n (%) | 155 (42.5) | 124 (51.5) | 279 (46.0) | 2 567 (42.7) | |
| >12 years of schooling, n (%) | 97 (26.6) | 78 (32.4) | 175 (28.9) | 1 669 (27.7) | |
| Missing, n | 8 | 6 | 14 | 182 |
P values (cases vs comparators): education, P = .061; Charlson Comorbidity Index (CCI), P = <.001.
Cutoff in landmark analysis is 12 months; patients with a HD-ASCT thereafter will remain unexposed in the analysis.
Fifty-five patients with MCL have a follow-up shorter than 12 months and do not contribute to the analysis.
Patients are matched on birth year, not exact age; therefore, the coherence is not perfect.