Table 4.

Within-patient variance and variance explained by antibodies in patients with temporarily decreased IR in pathfinder6

ModelWithin-patient varianceVariance explained (%)
Reference 0.68 
Only anti-PEG IgG 0.28 58.4 
Only anti-PEG IgM 0.61 10.3 
Only anti–N8-GP-binding 0.58 14.2 
Full model 0.26 62.3 
ModelWithin-patient varianceVariance explained (%)
Reference 0.68 
Only anti-PEG IgG 0.28 58.4 
Only anti-PEG IgM 0.61 10.3 
Only anti–N8-GP-binding 0.58 14.2 
Full model 0.26 62.3 

Temporarily decreased IR was defined as patients with an observation of 2 consecutive measurements of IR <0.6 (IU/dL)/(IU/kg) without inhibitors. Within-subject variance and variance explained were determined by coefficient of determination and R2 values.

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