Baseline characteristics
Patient . | Sex . | Disease status . | Subtype . | Location . | EMD . | Histology % PCs . | FACS . | Immunoparesis . | FISH . | |
---|---|---|---|---|---|---|---|---|---|---|
% PCs after sorting . | Viability . | |||||||||
NDMM01 | Male | New | IgG κ | Bone marrow | N | 10 | 96 | 92 | No | Normal |
L2 | 20 | 96 | 90 | |||||||
NDMM02 | Male | New | IgG λ | Bone marrow | N | 70 | 97 | 98 | Yes | HD, del13, del15, IgH unknown |
Iliac crest (L) | 60 | 99 | 94 | |||||||
NDMM03 | Female | New | λ | Bone marrow | N | 10 | 91 | 97 | Yes | IgH unknown |
Sacrum | 50 | 78 | 96 | |||||||
NDMM04 | Female | New | IgG κ | Bone marrow | N | 25 | 95 | 89 | No | HD (both) |
Iliac crest (R) | 25 | 72 | 92 | |||||||
NDMM05 | Female | New | IgA κ | Bone marrow | N | 60 | 100 | 100 | Yes | del13, del16, del17, gain8, gain15, t(11;14) |
T10 | 80 | 100 | 97 | |||||||
L4 | 80 | 100 | 97 | |||||||
NDMM06 | Female | New | IgG κ | Bone marrow | N | 30 | 96 | 89 | No | del13, del16, t(11;14) (both) |
L4 | 30 | 92 | 90 | |||||||
NDMM07 | Male | New | IgG κ | Bone marrow | N | 95 | 100 | 99 | Yes | del1p, HD |
Iliac crest (L) | 95 | 100 | 99 | |||||||
NDMM08 | Male | New | κ | Bone marrow | Y | 4 | 92 | 45 | Yes | Normal (both) |
Clavicle | 100 | NA | NA | |||||||
NDMM09 | Female | New | IgG κ | Bone marrow | N | 1 | 77 | 91 | No | Normal |
L3 | 10 | 79 | 89 | |||||||
NDMM10 | Female | New | κ | Bone marrow | N | MRD neg | 68 | 44 | No | Normal (both) |
Iliac crest (R) | MRD pos | 70 | 88 | |||||||
RRMM01 | Female | Relapse | IgA κ | Skin thigh (R) | Y | 100 | NA | NA | Yes | Normal |
Scaral lesion | 100 | |||||||||
RRMM02 | Male | Relapse | IgA κ/λ | Bone marrow | Y | 5 | 91 | 81 | No | gain1, t(MYC) |
Clavicle (R) | 100 | NA | 92 | |||||||
RRMM03 | Male | Relapse | λ | Bone marrow | N | 4 | 85 | 71 | No | del13, t(11;14) in OL negative in bone marrow |
L3 | 50 | 95 | 40 | |||||||
RRMM04 | Female | Relapse | IgG κ | Bone marrow | N | 79 | 99 | 98 | No | HD (gain1 3 and 4 copies), del4, del13, del 16, t(MYC) (both) |
T12 | 83 | 98 | 91 | |||||||
RRMM05 | Male | Relapse | IgG κ | Bone marrow | N | 15 | 97 | 87 | Yes | del16, del17 (both) |
Iliac crest (R) | 15 | 99 | 90 | |||||||
RRMM06 | Male | Relapse | κ | Bone marrow | Y | 35 | 99 | 99 | Yes | |
Paravertebral | 100 | NA | NA | |||||||
RRMM07 | Male | Relapse | IgD κ | Bone marrow (L) | N | 20 | 96 | 83 | Yes | TP53 del and 1q gain for both |
Bone marrow (R) | 82 | 96 | 72 | |||||||
RRMM08 | Male | Relapse | IgG λ | Bone marrow | N | 60 | 87 | 90 | Yes | gain5-17 3-4 copies, gain1 5-7 copies (both) |
Iliac crest (R) | 60 | 94 | 85 |
Patient . | Sex . | Disease status . | Subtype . | Location . | EMD . | Histology % PCs . | FACS . | Immunoparesis . | FISH . | |
---|---|---|---|---|---|---|---|---|---|---|
% PCs after sorting . | Viability . | |||||||||
NDMM01 | Male | New | IgG κ | Bone marrow | N | 10 | 96 | 92 | No | Normal |
L2 | 20 | 96 | 90 | |||||||
NDMM02 | Male | New | IgG λ | Bone marrow | N | 70 | 97 | 98 | Yes | HD, del13, del15, IgH unknown |
Iliac crest (L) | 60 | 99 | 94 | |||||||
NDMM03 | Female | New | λ | Bone marrow | N | 10 | 91 | 97 | Yes | IgH unknown |
Sacrum | 50 | 78 | 96 | |||||||
NDMM04 | Female | New | IgG κ | Bone marrow | N | 25 | 95 | 89 | No | HD (both) |
Iliac crest (R) | 25 | 72 | 92 | |||||||
NDMM05 | Female | New | IgA κ | Bone marrow | N | 60 | 100 | 100 | Yes | del13, del16, del17, gain8, gain15, t(11;14) |
T10 | 80 | 100 | 97 | |||||||
L4 | 80 | 100 | 97 | |||||||
NDMM06 | Female | New | IgG κ | Bone marrow | N | 30 | 96 | 89 | No | del13, del16, t(11;14) (both) |
L4 | 30 | 92 | 90 | |||||||
NDMM07 | Male | New | IgG κ | Bone marrow | N | 95 | 100 | 99 | Yes | del1p, HD |
Iliac crest (L) | 95 | 100 | 99 | |||||||
NDMM08 | Male | New | κ | Bone marrow | Y | 4 | 92 | 45 | Yes | Normal (both) |
Clavicle | 100 | NA | NA | |||||||
NDMM09 | Female | New | IgG κ | Bone marrow | N | 1 | 77 | 91 | No | Normal |
L3 | 10 | 79 | 89 | |||||||
NDMM10 | Female | New | κ | Bone marrow | N | MRD neg | 68 | 44 | No | Normal (both) |
Iliac crest (R) | MRD pos | 70 | 88 | |||||||
RRMM01 | Female | Relapse | IgA κ | Skin thigh (R) | Y | 100 | NA | NA | Yes | Normal |
Scaral lesion | 100 | |||||||||
RRMM02 | Male | Relapse | IgA κ/λ | Bone marrow | Y | 5 | 91 | 81 | No | gain1, t(MYC) |
Clavicle (R) | 100 | NA | 92 | |||||||
RRMM03 | Male | Relapse | λ | Bone marrow | N | 4 | 85 | 71 | No | del13, t(11;14) in OL negative in bone marrow |
L3 | 50 | 95 | 40 | |||||||
RRMM04 | Female | Relapse | IgG κ | Bone marrow | N | 79 | 99 | 98 | No | HD (gain1 3 and 4 copies), del4, del13, del 16, t(MYC) (both) |
T12 | 83 | 98 | 91 | |||||||
RRMM05 | Male | Relapse | IgG κ | Bone marrow | N | 15 | 97 | 87 | Yes | del16, del17 (both) |
Iliac crest (R) | 15 | 99 | 90 | |||||||
RRMM06 | Male | Relapse | κ | Bone marrow | Y | 35 | 99 | 99 | Yes | |
Paravertebral | 100 | NA | NA | |||||||
RRMM07 | Male | Relapse | IgD κ | Bone marrow (L) | N | 20 | 96 | 83 | Yes | TP53 del and 1q gain for both |
Bone marrow (R) | 82 | 96 | 72 | |||||||
RRMM08 | Male | Relapse | IgG λ | Bone marrow | N | 60 | 87 | 90 | Yes | gain5-17 3-4 copies, gain1 5-7 copies (both) |
Iliac crest (R) | 60 | 94 | 85 |
FLC, free light chain; Hb, hemoglobin; HD, hyperdiploid; L, left, LDH, lactate dehydrogenase; N, no; NA, not available; R, right; Y, yes.