ICANS predictors
| Variable . | Odds ratio . | 95% confidence interval . | P value . |
|---|---|---|---|
| Prelymphodepletion cGFAP | 1.10 | 0.69-1.79 | .7 |
| Prelymphodepletion cNfL | 0.81 | 0.49-1.31 | .4 |
| Day 1 sNfL | 1.09 | 0.77-1.57 | .6 |
| Cohort 1 | |||
| Cohort 2 | 1.33 | 0.63-2.86 | .5 |
| Cohort 3 | 0.81 | 0.28-2.26 | .7 |
| Age at CAR T-cell infusion | 1.05 | 0.99-1.10 | .086 |
| Sex | 0.95 | 0.48-1.88 | .9 |
| No. of relapses | 0.96 | 0.68-1.35 | .8 |
| Hematopoietic stem cell transplant, n | 0.74 | 0.41-1.31 | .3 |
| No radiation | |||
| TBI | 0.92 | 0.42-1.97 | |
| TBI + cranial boost | 1.76 | 0.65-4.95 | .4 |
| CNS 1 | |||
| CNS 2 | 0.69 | 0.28-1.62 | .4 |
| CNS 3 | 1.10 | 0.04-28.2 | >.9 |
| Neurocomorbidities | 1.35 | 0.68-2.69 | .4 |
| Peripheral neuropathy | 1.57 | 0.64-3.95 | .3 |
| No CRS | |||
| Mild CRS | 17.3 | 3.36-318 | .006 |
| Severe CRS | 34.0 | 5.33-679 | .002 |
| Variable . | Odds ratio . | 95% confidence interval . | P value . |
|---|---|---|---|
| Prelymphodepletion cGFAP | 1.10 | 0.69-1.79 | .7 |
| Prelymphodepletion cNfL | 0.81 | 0.49-1.31 | .4 |
| Day 1 sNfL | 1.09 | 0.77-1.57 | .6 |
| Cohort 1 | |||
| Cohort 2 | 1.33 | 0.63-2.86 | .5 |
| Cohort 3 | 0.81 | 0.28-2.26 | .7 |
| Age at CAR T-cell infusion | 1.05 | 0.99-1.10 | .086 |
| Sex | 0.95 | 0.48-1.88 | .9 |
| No. of relapses | 0.96 | 0.68-1.35 | .8 |
| Hematopoietic stem cell transplant, n | 0.74 | 0.41-1.31 | .3 |
| No radiation | |||
| TBI | 0.92 | 0.42-1.97 | |
| TBI + cranial boost | 1.76 | 0.65-4.95 | .4 |
| CNS 1 | |||
| CNS 2 | 0.69 | 0.28-1.62 | .4 |
| CNS 3 | 1.10 | 0.04-28.2 | >.9 |
| Neurocomorbidities | 1.35 | 0.68-2.69 | .4 |
| Peripheral neuropathy | 1.57 | 0.64-3.95 | .3 |
| No CRS | |||
| Mild CRS | 17.3 | 3.36-318 | .006 |
| Severe CRS | 34.0 | 5.33-679 | .002 |
Univariate model, P values < .05 are in bold.
CNS, central nervous system.