Changes in the prevalence of CRAB symptoms at first relapse in patients who experienced a particular CRAB symptom at diagnosis compared with patients without this particular CRAB symptom at diagnosis in the clinical progression group (n = 534)
| At first relapse At baseline . | C: Hypercalcemia . | R: Renal insufficiency . | A: Anemia . | B: New bone disease . |
|---|---|---|---|---|
| C: Hypercalcemia | P = .004 OR, 3.3 95% CI, 1.4-7.5 | NS | NS | NS |
| R: Renal insufficiency | NS | P < .001 OR, 3.6 95% CI, 1.9-6.7 | NS | NS |
| A: Anemia | NS | P = .02 OR, 1.9 95% CI, 1.1-3.5 | P < .001 OR, 2.1 95% CI, 1.4-3.2 | P = .001 OR, 0.4 95% CI, 0.3-0.6 |
| B: Bone disease | NS | P = .01 OR, 0.5 95% CI, 0.3-0.8 | P < .001 OR, 0.4 95% CI, 0.3-0.6 | P < .001 OR, 2.2 95% CI, 1.5-3.4 |
| At first relapse At baseline . | C: Hypercalcemia . | R: Renal insufficiency . | A: Anemia . | B: New bone disease . |
|---|---|---|---|---|
| C: Hypercalcemia | P = .004 OR, 3.3 95% CI, 1.4-7.5 | NS | NS | NS |
| R: Renal insufficiency | NS | P < .001 OR, 3.6 95% CI, 1.9-6.7 | NS | NS |
| A: Anemia | NS | P = .02 OR, 1.9 95% CI, 1.1-3.5 | P < .001 OR, 2.1 95% CI, 1.4-3.2 | P = .001 OR, 0.4 95% CI, 0.3-0.6 |
| B: Bone disease | NS | P = .01 OR, 0.5 95% CI, 0.3-0.8 | P < .001 OR, 0.4 95% CI, 0.3-0.6 | P < .001 OR, 2.2 95% CI, 1.5-3.4 |
Hypercalcemia is defined as calcium >11.5 mg/dL; renal insufficiency at progression is defined as increase in serum creatinine >2 mg/dL; anemia is defined as a decrease in hemoglobin ≥2 g/dL or to ≤10 g/dL; new bone disease is defined as an increase ≥50% in size or new plasmacytomas/bone lesions.
NS, not significant; OR, odds ratio.