Summary of toxicity
| . | n (%) . | |||
|---|---|---|---|---|
| Grade 1 . | Grade 2 . | Grade 3 . | Grade 4 . | |
| Severe AEs | ||||
| Transaminitis | 2 (10) | |||
| Abdominal pain | 1 (5) | |||
| Colitis | 1 (5) | |||
| Diarrhea | 1 (5) | |||
| Headache | 1 (5) | |||
| Respiratory failure | 1 (5) | |||
| trAE | ||||
| Transaminitis | 1 (5) | 2 (10) | ||
| Abdominal pain | 1 (5) | 1 (5) | ||
| Arthralgia | 1 (5) | 1 (5) | ||
| Diarrhea | 1 (5) | 1 (5) | ||
| Hypothyroidism | 1 (5) | 2 (10) | ||
| Arthralgia | 1 (5) | |||
| Colitis | 1 (5) | |||
| Dizziness | 1 (5) | |||
| Elevated ALP | 1 (5) | |||
| Flu-like symptoms | 1 (5) | |||
| Hyperthyroidism | 1 (5) | |||
| Nasal congestion | 1 (5) | |||
| Nausea | 1 (5) | |||
| Neuralgia | 1 (5) | |||
| Noncardiac chest pain | 1 (5) | |||
| Weight loss | 1 (5) | |||
| irAE | ||||
| Transaminitis | 1 (5) | 2 (10) | ||
| Hypothyroidism | 1 (5) | 2 (10) | ||
| Arthralgia | 1 (5) | 1 (5) | ||
| Diarrhea | 1 (5) | 1 (5) | ||
| Colitis | 1 (5) | |||
| Elevated ALP | 1 (5) | |||
| Hyperthyroidism | 1 (5) | |||
| . | n (%) . | |||
|---|---|---|---|---|
| Grade 1 . | Grade 2 . | Grade 3 . | Grade 4 . | |
| Severe AEs | ||||
| Transaminitis | 2 (10) | |||
| Abdominal pain | 1 (5) | |||
| Colitis | 1 (5) | |||
| Diarrhea | 1 (5) | |||
| Headache | 1 (5) | |||
| Respiratory failure | 1 (5) | |||
| trAE | ||||
| Transaminitis | 1 (5) | 2 (10) | ||
| Abdominal pain | 1 (5) | 1 (5) | ||
| Arthralgia | 1 (5) | 1 (5) | ||
| Diarrhea | 1 (5) | 1 (5) | ||
| Hypothyroidism | 1 (5) | 2 (10) | ||
| Arthralgia | 1 (5) | |||
| Colitis | 1 (5) | |||
| Dizziness | 1 (5) | |||
| Elevated ALP | 1 (5) | |||
| Flu-like symptoms | 1 (5) | |||
| Hyperthyroidism | 1 (5) | |||
| Nasal congestion | 1 (5) | |||
| Nausea | 1 (5) | |||
| Neuralgia | 1 (5) | |||
| Noncardiac chest pain | 1 (5) | |||
| Weight loss | 1 (5) | |||
| irAE | ||||
| Transaminitis | 1 (5) | 2 (10) | ||
| Hypothyroidism | 1 (5) | 2 (10) | ||
| Arthralgia | 1 (5) | 1 (5) | ||
| Diarrhea | 1 (5) | 1 (5) | ||
| Colitis | 1 (5) | |||
| Elevated ALP | 1 (5) | |||
| Hyperthyroidism | 1 (5) | |||
Values are n (%), unless otherwise specified.
Therapy related AEs (trAEs): all AEs attributed as at least possibly related to study treatment. Severe AEs: all grade ≥3 AEs regardless of attribution. irAEs: all AEs considered to be immune-related by the investigator.
ALP, alkaline phosphatase.