Overall baseline patient characteristics and based on cardiac events
| . | Total cohort (N = 78) . | No cardiac events (N = 67) . | Cardiac events (N = 11) . | P value . |
|---|---|---|---|---|
| Age at CAR-T | 64.1 ± 8.7 | 63.7 ± 8.5 | 67.0 ± 9.7 | .243 |
| Sex | .048 | |||
| Male | 46 (59.0%) | 43 (64.2%) | 3 (27.3%) | |
| Female | 32 (41.0%) | 24 (35.8%) | 8 (72.7%) | |
| Ethnicity | .053 | |||
| White | 58 (74.4%) | 53 (79.1%) | 5 (45.5%) | |
| Black | 12 (15.4%) | 8 (11.9%) | 4 (36.4%) | |
| Other | 8 (10.3%) | 6 (9.0%) | 2 (18.2%) | |
| Baseline ECOG | < .001 | |||
| 0 | 26 (33.3%) | 24 (35.8%) | 2 (18.2%) | |
| 1 | 41 (52.6%) | 38 (56.7%) | 3 (27.3%) | |
| 2 | 7 (9.0%) | 3 (4.5%) | 4 (36.4%) | |
| 3 | 3 (3.8%) | 1 (1.5%) | 2 (18.2%) | |
| 4 | 1 (1.3%) | 1 (1.5%) | 0 (0.0%) | |
| Body surface area (m2) | 2.0 (1.7-2.1) | 1.9 ± 0.2 | 1.8 ± 0.4 | .415 |
| Heart rate (bpm) | 85.0 (75.0-96.0) | 84.0 (74.5-94.5) | 95.0 (80.5-100.0) | .153 |
| Systolic BP (mmHg) | 122.0 ± 17.4 | 122.3 ± 17.1 | 120.7 ± 19.5 | .789 |
| Diastolic BP (mmHg) | 75.2 ± 9.5 | 75.7 ± 9.1 | 71.9 ± 11.2 | .221 |
| White blood cell (×1000/μL) | 3.9 (2.9-5.2) | 4.0 (3.1-5.2) | 3.5 (2.8-4.7) | .409 |
| Hemoglobin (g/dL) | 10.1 (9.2-11.2) | 10.0 (9.1-11.2) | 10.2 (9.5-10.8) | .954 |
| Platelet (×1000/μL) | 137.0 (90.0-189.0) | 147.8 ± 73.9 | 112.0 ± 66.5 | .136 |
| Creatinine (mg/dL) | 0.9 (0.7-1.1) | 0.9 (0.7-1.1) | 0.9 (0.6-1.4) | .789 |
| . | Total cohort (N = 78) . | No cardiac events (N = 67) . | Cardiac events (N = 11) . | P value . |
|---|---|---|---|---|
| Age at CAR-T | 64.1 ± 8.7 | 63.7 ± 8.5 | 67.0 ± 9.7 | .243 |
| Sex | .048 | |||
| Male | 46 (59.0%) | 43 (64.2%) | 3 (27.3%) | |
| Female | 32 (41.0%) | 24 (35.8%) | 8 (72.7%) | |
| Ethnicity | .053 | |||
| White | 58 (74.4%) | 53 (79.1%) | 5 (45.5%) | |
| Black | 12 (15.4%) | 8 (11.9%) | 4 (36.4%) | |
| Other | 8 (10.3%) | 6 (9.0%) | 2 (18.2%) | |
| Baseline ECOG | < .001 | |||
| 0 | 26 (33.3%) | 24 (35.8%) | 2 (18.2%) | |
| 1 | 41 (52.6%) | 38 (56.7%) | 3 (27.3%) | |
| 2 | 7 (9.0%) | 3 (4.5%) | 4 (36.4%) | |
| 3 | 3 (3.8%) | 1 (1.5%) | 2 (18.2%) | |
| 4 | 1 (1.3%) | 1 (1.5%) | 0 (0.0%) | |
| Body surface area (m2) | 2.0 (1.7-2.1) | 1.9 ± 0.2 | 1.8 ± 0.4 | .415 |
| Heart rate (bpm) | 85.0 (75.0-96.0) | 84.0 (74.5-94.5) | 95.0 (80.5-100.0) | .153 |
| Systolic BP (mmHg) | 122.0 ± 17.4 | 122.3 ± 17.1 | 120.7 ± 19.5 | .789 |
| Diastolic BP (mmHg) | 75.2 ± 9.5 | 75.7 ± 9.1 | 71.9 ± 11.2 | .221 |
| White blood cell (×1000/μL) | 3.9 (2.9-5.2) | 4.0 (3.1-5.2) | 3.5 (2.8-4.7) | .409 |
| Hemoglobin (g/dL) | 10.1 (9.2-11.2) | 10.0 (9.1-11.2) | 10.2 (9.5-10.8) | .954 |
| Platelet (×1000/μL) | 137.0 (90.0-189.0) | 147.8 ± 73.9 | 112.0 ± 66.5 | .136 |
| Creatinine (mg/dL) | 0.9 (0.7-1.1) | 0.9 (0.7-1.1) | 0.9 (0.6-1.4) | .789 |
All values are at the time of baseline lymphodepletion.
Data are presented as mean ± SD, median (interquartile range), or number (percentage), depending on the type of data.
P < .05 is bolded.
BP, blood pressure; bpm, beats per minute.