Table 2. Plasma protease selectivity... | American Society of Hematology

Table 2.

Plasma protease selectivity profile of SAR443809

Plasma protease	EC₅₀ (ng/mL)∗
Human complement factor Bb	30.9 (8.6-131.1)
Human complement factor B	364.8 (0.01-14090938.19)†
Human complement C2	No binding
Human Complement C2a	No binding
Human Complement C1s	No binding
Human Complement aC1s	No binding
Human Complement C1r	No binding
MASP1	>50 μg/mL‡
MASP2	>50 μg/mL‡
Human complement factor D	No binding
Elastase, human neutrophil	No binding
Thrombin, human plasma	No binding

Plasma protease	EC₅₀ (ng/mL)∗
Human complement factor Bb	30.9 (8.6-131.1)
Human complement factor B	364.8 (0.01-14090938.19)†
Human complement C2	No binding
Human Complement C2a	No binding
Human Complement C1s	No binding
Human Complement aC1s	No binding
Human Complement C1r	No binding
MASP1	>50 μg/mL‡
MASP2	>50 μg/mL‡
Human complement factor D	No binding
Elastase, human neutrophil	No binding
Thrombin, human plasma	No binding

CI, confidence interval; EC₅₀, half-maximal effective concentration.

Geometric mean of the EC₅₀ of the biological replicates along with the 95% CI.

very broad 95% CI – unreliable values.

Repeat experiment with new lot of MASP1 and MASP2 showed no binding.