Table 1. Phenotype differences due to... | American Society of Hematology

Table 1.

Phenotype differences due to platelet-specific deletion of murine PITPα, PITPβ, or both isoforms compared with those in wild-type controls

	PITPα-null	PITPβ-null	PITPα/β-null
Platelet count	Reduced by 15%	Reduced by 15%	Reduced by 40%
Aggregation	Normal	Normal	Impaired
Dense granule secretion (ATP)	Normal	Impaired	More severe
Platelet spreading	Normal	Normal	Impaired
In vivo thrombosis	Normal	N/A	Normal
In vivo α-granule secretion (P-selectin)	Normal	N/A	Normal
Hemostasis: tail bleeding time	Normal	Normal	150 s vs 35 s
Tumor metastases	Fewer	Fewer	Markedly fewer
Platelet adhesion to tumor cells	Decreased	Decreased	Decreased
In vitro thrombin generation	Impaired	Impaired	Completely eliminated
PtdInsP response	Normal	Normal	Decreased
IP₃ formation	Decreased	Decreased	More severe

	PITPα-null	PITPβ-null	PITPα/β-null
Platelet count	Reduced by 15%	Reduced by 15%	Reduced by 40%
Aggregation	Normal	Normal	Impaired
Dense granule secretion (ATP)	Normal	Impaired	More severe
Platelet spreading	Normal	Normal	Impaired
In vivo thrombosis	Normal	N/A	Normal
In vivo α-granule secretion (P-selectin)	Normal	N/A	Normal
Hemostasis: tail bleeding time	Normal	Normal	150 s vs 35 s
Tumor metastases	Fewer	Fewer	Markedly fewer
Platelet adhesion to tumor cells	Decreased	Decreased	Decreased
In vitro thrombin generation	Impaired	Impaired	Completely eliminated
PtdInsP response	Normal	Normal	Decreased
IP₃ formation	Decreased	Decreased	More severe

ATP, adenosine triphosphate; N/A indicates that experiments were not performed; PtdInsP, phosphatidylinositol monophosphate.