Participant demographics and key baseline characteristics
| . | 6 mo-1.99 y (N = 6) . | 2-5.99 y (N = 16) . | 6-17.99 y (N = 10) . | Overall (N = 32) . |
|---|---|---|---|---|
| Age (y), mean (SD) | 1.0 (0.1) | 3.1 (0.9) | 10.7 (3.5) | 5.0 (4.3) |
| Female sex, n (%) | 5 (83) | 5 (31) | 6 (60) | 16 (50) |
| SCA type, n (%) | ||||
| HbSS | 6 (100) | 15 (94) | 10 (100) | 32 (97) |
| HbS/ß0 | 0 | 1 (6) | 0 | 1 (3) |
| Height (cm), mean (SD) | 79.4 (5.2) | 98.1 (6.9) | 142.1 (15.9) | 109.3 (26.0) |
| Weight (kg), mean (SD) | 11.2 (1.0) | 14.7 (2.1) | 32.5 (11.4) | 19.6 (11.0) |
| Total number of days on liquid hydroxyurea, median (range) | 287 (112-435) | 397 (150-433) | 388 (257-432) | 373 (112-435) |
| Dose at study exit (mg/kg), mean (SD) | 23.0 (6.8) | 26.5 (5.5) | 26.5 (5.3) | 25.8 (5.7) |
| . | 6 mo-1.99 y (N = 6) . | 2-5.99 y (N = 16) . | 6-17.99 y (N = 10) . | Overall (N = 32) . |
|---|---|---|---|---|
| Age (y), mean (SD) | 1.0 (0.1) | 3.1 (0.9) | 10.7 (3.5) | 5.0 (4.3) |
| Female sex, n (%) | 5 (83) | 5 (31) | 6 (60) | 16 (50) |
| SCA type, n (%) | ||||
| HbSS | 6 (100) | 15 (94) | 10 (100) | 32 (97) |
| HbS/ß0 | 0 | 1 (6) | 0 | 1 (3) |
| Height (cm), mean (SD) | 79.4 (5.2) | 98.1 (6.9) | 142.1 (15.9) | 109.3 (26.0) |
| Weight (kg), mean (SD) | 11.2 (1.0) | 14.7 (2.1) | 32.5 (11.4) | 19.6 (11.0) |
| Total number of days on liquid hydroxyurea, median (range) | 287 (112-435) | 397 (150-433) | 388 (257-432) | 373 (112-435) |
| Dose at study exit (mg/kg), mean (SD) | 23.0 (6.8) | 26.5 (5.5) | 26.5 (5.3) | 25.8 (5.7) |
For age, 0.99 denotes the day before the study participant’s birthday.
N, number of subjects in the population; SCA, sickle cell anemia.