Demographics and immune thrombocytopenia characteristics
| . | Pregnant women with ITP followed up to delivery (n = 171) . | Matched pregnant women with ITP, exposed (n = 131) . | Matched nonpregnant women with ITP, non-exposed (n = 131) . | P Value∗ . |
|---|---|---|---|---|
| Age at ITP diagnosis, y, median (IQR) | 24.1 (18.4, 28.1) | 24.2 (19.4, 28.1) | 23.7 (18.0, 30.8) | .38 |
| Age at enrollment, y, median (IQR) | 30.4 (26.9, 34.5) | 30.4 (26.7, 34.9) | 31.4 (24.4, 37.9) | .45 |
| Age at pregnancy diagnosis, y, median (IQR) | 30.1 (26.9, 34.1) | 30.4 (26.4, 34.6) | ||
| Women with at least 1 prior pregnancy | 116 (67.8) | 90 (68.7) | ||
| Women with at least 1 prior pregnancy after ITP diagnosis (n = 115/89) | 81 (70.4) | 62 (69.7) | ||
| Neonatal thrombocytopenia occuring at previous pregnancy after ITP diagnosis (n = 78/61) | 21 (26.9) | 14 (23) | ||
| ITP previous treatment | ||||
| No treatment | 60 (35.1) | 47 (35.9) | 33 (25.2) | .06 |
| If yes, no. of lines, median (IQR) | 2 (1-3) | 2 (1-3) | 2 (2-3) | .92 |
| Splenectomy | 22 (12.9) | 17 (13) | 17 (13) | 1 |
| ITP duration at pregnancy diagnosis (pregnant women with ITP) or at time of inclusion (nonpregnant women with ITP) | 1 | |||
| Persistent | 10 (5.8) | 9 (6.9) | 9 (6.9) | |
| Chronic | 161 (94.2) | 122 (93.1) | 122 (93.1) | |
| ITP status at pregnancy diagnosis or at time of inclusion (controls) | 1 | |||
| CR | 85 (49.7) | 50 (38.2) | 50 (38.2) | |
| R | 69 (40.4) | 64 (48.8) | 64 (48.8) | |
| NR | 17 (9.9) | 17 (13.0) | 17 (13.0) |
| . | Pregnant women with ITP followed up to delivery (n = 171) . | Matched pregnant women with ITP, exposed (n = 131) . | Matched nonpregnant women with ITP, non-exposed (n = 131) . | P Value∗ . |
|---|---|---|---|---|
| Age at ITP diagnosis, y, median (IQR) | 24.1 (18.4, 28.1) | 24.2 (19.4, 28.1) | 23.7 (18.0, 30.8) | .38 |
| Age at enrollment, y, median (IQR) | 30.4 (26.9, 34.5) | 30.4 (26.7, 34.9) | 31.4 (24.4, 37.9) | .45 |
| Age at pregnancy diagnosis, y, median (IQR) | 30.1 (26.9, 34.1) | 30.4 (26.4, 34.6) | ||
| Women with at least 1 prior pregnancy | 116 (67.8) | 90 (68.7) | ||
| Women with at least 1 prior pregnancy after ITP diagnosis (n = 115/89) | 81 (70.4) | 62 (69.7) | ||
| Neonatal thrombocytopenia occuring at previous pregnancy after ITP diagnosis (n = 78/61) | 21 (26.9) | 14 (23) | ||
| ITP previous treatment | ||||
| No treatment | 60 (35.1) | 47 (35.9) | 33 (25.2) | .06 |
| If yes, no. of lines, median (IQR) | 2 (1-3) | 2 (1-3) | 2 (2-3) | .92 |
| Splenectomy | 22 (12.9) | 17 (13) | 17 (13) | 1 |
| ITP duration at pregnancy diagnosis (pregnant women with ITP) or at time of inclusion (nonpregnant women with ITP) | 1 | |||
| Persistent | 10 (5.8) | 9 (6.9) | 9 (6.9) | |
| Chronic | 161 (94.2) | 122 (93.1) | 122 (93.1) | |
| ITP status at pregnancy diagnosis or at time of inclusion (controls) | 1 | |||
| CR | 85 (49.7) | 50 (38.2) | 50 (38.2) | |
| R | 69 (40.4) | 64 (48.8) | 64 (48.8) | |
| NR | 17 (9.9) | 17 (13.0) | 17 (13.0) |
All results are given as number of events (%) unless otherwise specified. n is specified only when data are missing.
CR, complete response; IQR, interquartile range; ITP, immune thrombocytopenia; NR, nonresponse; R, response.
Mixed logistic regression model.