The effect of HLA-DR alleles on cGVHD development (F-to-M cohort)
| HLA-DR alleles . | n . | Frequency (%) . | Cumulative incidence of cGVHD . | ||
|---|---|---|---|---|---|
| HR . | 95% CI . | P value . | |||
| DRB1∗01:01 | 74 | 9.6 | 0.84 | (0.58-1.21) | .34 |
| DRB1∗04:03 | 42 | 5.5 | 1.08 | (0.71-1.66) | .72 |
| DRB1∗04:05 | 173 | 22.5 | 0.80 | (0.63-1.02) | .068 |
| DRB1∗04:06 | 46 | 6.0 | 0.86 | (0.56-1.35) | .52 |
| DRB1∗08:02 | 44 | 5.7 | 1.01 | (0.64-1.60) | .95 |
| DRB1∗08:03 | 104 | 13.5 | 1.02 | (0.78-1.34) | .89 |
| DRB1∗09:01 | 228 | 29.7 | 0.74 | (0.59-0.93) | .010 |
| DRB1∗11:01 | 45 | 5.9 | 1.14 | (0.75-1.74) | .53 |
| DRB1∗12:01 | 46 | 6.0 | 0.63 | (0.39-1.01) | .053 |
| DRB1∗13:02 | 81 | 10.5 | 1.16 | (0.84-1.60) | .36 |
| DRB1∗14:54 | 47 | 6.1 | 1.36 | (0.89-2.07) | .15 |
| DRB1∗15:01 | 130 | 16.9 | 1.11 | (0.86-1.42) | .43 |
| DRB1∗15:02 | 167 | 21.7 | 1.28 | (1.03-1.58) | .025 |
| HLA-DR alleles . | n . | Frequency (%) . | Cumulative incidence of cGVHD . | ||
|---|---|---|---|---|---|
| HR . | 95% CI . | P value . | |||
| DRB1∗01:01 | 74 | 9.6 | 0.84 | (0.58-1.21) | .34 |
| DRB1∗04:03 | 42 | 5.5 | 1.08 | (0.71-1.66) | .72 |
| DRB1∗04:05 | 173 | 22.5 | 0.80 | (0.63-1.02) | .068 |
| DRB1∗04:06 | 46 | 6.0 | 0.86 | (0.56-1.35) | .52 |
| DRB1∗08:02 | 44 | 5.7 | 1.01 | (0.64-1.60) | .95 |
| DRB1∗08:03 | 104 | 13.5 | 1.02 | (0.78-1.34) | .89 |
| DRB1∗09:01 | 228 | 29.7 | 0.74 | (0.59-0.93) | .010 |
| DRB1∗11:01 | 45 | 5.9 | 1.14 | (0.75-1.74) | .53 |
| DRB1∗12:01 | 46 | 6.0 | 0.63 | (0.39-1.01) | .053 |
| DRB1∗13:02 | 81 | 10.5 | 1.16 | (0.84-1.60) | .36 |
| DRB1∗14:54 | 47 | 6.1 | 1.36 | (0.89-2.07) | .15 |
| DRB1∗15:01 | 130 | 16.9 | 1.11 | (0.86-1.42) | .43 |
| DRB1∗15:02 | 167 | 21.7 | 1.28 | (1.03-1.58) | .025 |
The effect of each HLA-DR allele on the development of cGVHD was calculated by the Fine-Gray method.