Genome-wide loci for proteinuria and eGFR meta-analyses
| Phenotype . | Gene . | Lead SNP . | Chr . | Position (b37) . | Meta P value (q-value)∗ . | Queried LD SNP . | TF binding sites† . | Chromatin state‡ . | Open chromatin§ . | TF binding motifsǁ . | eQTLs (NephQTL)¶ . |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Proteinuria | CRYL1 | rs9315599 | 13 | 21037608 | 2.38E-08 (1.20E-03) | rs4770035 | ZNF449, PRDM1 | quiescent/low | FOXA2, FOXI1, ZFP105 | GJB2 (TI) | |
| Proteinuria | VWF | rs2238104 | 12 | 6187665 | 7.26E-07 (2.33E-02) | ZNF366, ATF2, ZIC2, ZBTB21, CTCF, ZBTB17, ZNF660, PATZ1, ZNF629, WT1, GLIS1, ZIC2, ZNF189, ZFHX2 | strong transcription | kidney epithelial cells, renal cortical epithelial cells | CHD4 (GL), GAPDH (TI), CD9 (GL) | ||
| Proteinuria | ADAMTS7 | rs3743057 | 15 | 79089007 | 1.06E-06 (2.77E-02) | REST | strong transcription | ANKRD34C (TI), MORF4L1 (TI) | |||
| rs7182809 | SALL2, ZNF571, ZNF311, ZNF662 | strong transcription | |||||||||
| eGFR | LRP1B | rs1968911 | 2 | 141092882 | 3.07E-07 (5.17E-02) | rs12373750 | MAFK, RREB1 | ||||
| eGFR | linc02288 | rs4903539 | 14 | 77532688 | 1.09E-06 (5.17E-02) | strong transcription | HEK293T | NFATC1, NR2F1, NR2F6, RARA, RARB, RARG | NGB (TI) | ||
| eGFR | FPGT-TNNI3K/TNNI3K | rs7526762 | 1 | 74993318 | 1.51E-06 (5.17E-02) |
| Phenotype . | Gene . | Lead SNP . | Chr . | Position (b37) . | Meta P value (q-value)∗ . | Queried LD SNP . | TF binding sites† . | Chromatin state‡ . | Open chromatin§ . | TF binding motifsǁ . | eQTLs (NephQTL)¶ . |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Proteinuria | CRYL1 | rs9315599 | 13 | 21037608 | 2.38E-08 (1.20E-03) | rs4770035 | ZNF449, PRDM1 | quiescent/low | FOXA2, FOXI1, ZFP105 | GJB2 (TI) | |
| Proteinuria | VWF | rs2238104 | 12 | 6187665 | 7.26E-07 (2.33E-02) | ZNF366, ATF2, ZIC2, ZBTB21, CTCF, ZBTB17, ZNF660, PATZ1, ZNF629, WT1, GLIS1, ZIC2, ZNF189, ZFHX2 | strong transcription | kidney epithelial cells, renal cortical epithelial cells | CHD4 (GL), GAPDH (TI), CD9 (GL) | ||
| Proteinuria | ADAMTS7 | rs3743057 | 15 | 79089007 | 1.06E-06 (2.77E-02) | REST | strong transcription | ANKRD34C (TI), MORF4L1 (TI) | |||
| rs7182809 | SALL2, ZNF571, ZNF311, ZNF662 | strong transcription | |||||||||
| eGFR | LRP1B | rs1968911 | 2 | 141092882 | 3.07E-07 (5.17E-02) | rs12373750 | MAFK, RREB1 | ||||
| eGFR | linc02288 | rs4903539 | 14 | 77532688 | 1.09E-06 (5.17E-02) | strong transcription | HEK293T | NFATC1, NR2F1, NR2F6, RARA, RARB, RARG | NGB (TI) | ||
| eGFR | FPGT-TNNI3K/TNNI3K | rs7526762 | 1 | 74993318 | 1.51E-06 (5.17E-02) |
Evidence for GWAS locus regulatory function culled from RegulomeDB and eQTLs from NephQTL is listed for either the lead SNP or an identified proxy (queried LD SNP).
GL, glomerulus; TI, tubulointerstitium.
Meta-analysis P value and corresponding FDR q-value for respective GWAS of either proteinuria or eGFR.
TF binding sites in HEK293 cells identified via chromatin immunoprecipitation sequencing.
Chromatin state in kidney via chromatin immunoprecipitation sequencing followed by segmentation using ChromHMM.
Open chromatin peaks identified via formaldehyde-assisted isolation of regulatory elements (FAIRE)-sequencing and DNase sequencing.
TF binding motifs as determined using positional weight matrixes.
eQTLs from NephQTL in GL and kidney TI.