AEs among all the treated patients
| AEs . | Any grade . | Grade 1 . | Grade 2 . | Grade 3 . | Grade 4 . |
|---|---|---|---|---|---|
| Number of patients . | |||||
| CRS | 9 | 9 | 0 | 0 | 0 |
| Fatigue | 9 | 6 | 3 | 0 | 0 |
| ICANS | 0 | 0 | 0 | 0 | 0 |
| Hypertension | 5 | 2 | 3 | 0 | 0 |
| Sinus tachycardia | 5 | 3 | 2 | 0 | 0 |
| Coagulation disorders | 4 | 4 | 0 | 0 | 0 |
| Increased aspartate aminotransferase | 2 | 1 | 1 | 0 | 0 |
| Increased alanine aminotransferase | 2 | 1 | 1 | 0 | 0 |
| Cytopenia | |||||
| Neutropenia | 13 | 0 | 1 | 6 | 6 |
| Anemia | 12 | 2 | 7 | 3 | 0 |
| Thrombocytopenia | 10 | 2 | 5 | 1 | 2 |
| Lymphopenia | 13 | 1 | 6 | 6 | 0 |
| Hypogammaglobulinemia | 12 | 12 | 0 | 0 | 0 |
| Infection | |||||
| Sepsis | 1 | 0 | 0 | 1 | 0 |
| Shingles | 1 | 0 | 0 | 1 | 0 |
| Upper respiratory infection | 2 | 0 | 2 | 0 | 0 |
| Bacteria | 1 | 0 | 0 | 1 | 0 |
| AEs . | Any grade . | Grade 1 . | Grade 2 . | Grade 3 . | Grade 4 . |
|---|---|---|---|---|---|
| Number of patients . | |||||
| CRS | 9 | 9 | 0 | 0 | 0 |
| Fatigue | 9 | 6 | 3 | 0 | 0 |
| ICANS | 0 | 0 | 0 | 0 | 0 |
| Hypertension | 5 | 2 | 3 | 0 | 0 |
| Sinus tachycardia | 5 | 3 | 2 | 0 | 0 |
| Coagulation disorders | 4 | 4 | 0 | 0 | 0 |
| Increased aspartate aminotransferase | 2 | 1 | 1 | 0 | 0 |
| Increased alanine aminotransferase | 2 | 1 | 1 | 0 | 0 |
| Cytopenia | |||||
| Neutropenia | 13 | 0 | 1 | 6 | 6 |
| Anemia | 12 | 2 | 7 | 3 | 0 |
| Thrombocytopenia | 10 | 2 | 5 | 1 | 2 |
| Lymphopenia | 13 | 1 | 6 | 6 | 0 |
| Hypogammaglobulinemia | 12 | 12 | 0 | 0 | 0 |
| Infection | |||||
| Sepsis | 1 | 0 | 0 | 1 | 0 |
| Shingles | 1 | 0 | 0 | 1 | 0 |
| Upper respiratory infection | 2 | 0 | 2 | 0 | 0 |
| Bacteria | 1 | 0 | 0 | 1 | 0 |
Listed are the grade 1 to 2 AEs that occurred in at least 15% of the patients, and all events of grade 3 or higher occurred in patients from the time of infusion of CAR T cells until day 90. The severities of the AEs were graded according to the CTCAE version 5.0 except CRS and ICANS, which were graded according to the criteria of Lee et al10 and a revised grading system, respectively.