Summary of epidemiological studies regarding the association between MGUS and obesity
| Study and/or authors . | n . | Study design . | Results . |
|---|---|---|---|
| Southern Community Cohort Study20 | 60 patients with MGUS and 1936 controls | Case control study | Higher risk of MGUS in obese subjects (OR, 1.8; 95% CI, 1.03-3.14) |
| National Health and Nutritional Examination Survey26 | 365 patients with MGUS and 12 117 controls | Cohort study | MGUS prevalence appeared to increase with increasing BMI in both men and women but trend did not reach statistical significance |
| Age, Gene/Environment Susceptibility- Reykjavik (AGES)22 | 300 patients with MGUS and 5425 controls | Case control study | No association between MGUS and 11 different markers of obesity |
| Schimdt et al27 | 260 patients with MGUS and 4527 controls | Case control study | No association between MGUS and BMI |
| Boursi et al28 | 2363 patients with MGUS and 9193 controls | Case control study | Statistically significant association between obesity and MGUS (OR, 1.15; 95% CI, 1.02-1.29); however, this dissipated after adjustment (OR, 1.08; 95% CI, 0.96-1.22) |
| Study and/or authors . | n . | Study design . | Results . |
|---|---|---|---|
| Southern Community Cohort Study20 | 60 patients with MGUS and 1936 controls | Case control study | Higher risk of MGUS in obese subjects (OR, 1.8; 95% CI, 1.03-3.14) |
| National Health and Nutritional Examination Survey26 | 365 patients with MGUS and 12 117 controls | Cohort study | MGUS prevalence appeared to increase with increasing BMI in both men and women but trend did not reach statistical significance |
| Age, Gene/Environment Susceptibility- Reykjavik (AGES)22 | 300 patients with MGUS and 5425 controls | Case control study | No association between MGUS and 11 different markers of obesity |
| Schimdt et al27 | 260 patients with MGUS and 4527 controls | Case control study | No association between MGUS and BMI |
| Boursi et al28 | 2363 patients with MGUS and 9193 controls | Case control study | Statistically significant association between obesity and MGUS (OR, 1.15; 95% CI, 1.02-1.29); however, this dissipated after adjustment (OR, 1.08; 95% CI, 0.96-1.22) |
OR, odds ratio; CI, confidence interval.