Univariate and multivariate Cox regression analysis dependent on blast count (top) and TP53 state (bottom)
| . | Univariate . | Multivariate . | ||
|---|---|---|---|---|
| P value . | HR . | P value . | HR . | |
| Total cohort | ||||
| TP53 single hit | .043 | 1.4 | .003 | 1.6 |
| TP53 double hit | < .001 | 4.9 | < .001 | 3.9 |
| Blast count (<5%, ≥5%) | < .001 | 1.9 | < .001 | 1.8 |
| Complex karyotype | < .001 | 3.2 | .047 | 1.3 |
| MDS with <5% blasts | ||||
| TP53 single hit | .018 | 1.7 | .021 | 1.7 |
| TP53 double hit | < .001 | 4.9 | .041 | 2.2 |
| Complex karyotype | < .001 | 7.0 | < .001 | 5.2 |
| MDS with ≥5% but <10% blasts | ||||
| TP53 single hit | .028 | 2.2 | .026 | 2.3 |
| TP53 double hit | < .001 | 12.1 | < .001 | 9.2 |
| Complex karyotype | < .001 | 4.1 | ns | — |
| MDS with ≥10% but <20% blasts | ||||
| TP53 single hit | n.s. | — | — | — |
| TP53 double hit | < .001 | 5.6 | .004 | 4.6 |
| Complex karyotype | < .001 | 3.2 | ns | — |
| AML | ||||
| TP53 single hit | .039 | 1.5 | .044 | 1.6 |
| TP53 double hit | < .001 | 4.4 | < .001 | 4.2 |
| Complex karyotype | < .001 | 2.6 | n.s. | — |
| . | Univariate . | Multivariate . | ||
|---|---|---|---|---|
| P value . | HR . | P value . | HR . | |
| Total cohort | ||||
| TP53 single hit | .043 | 1.4 | .003 | 1.6 |
| TP53 double hit | < .001 | 4.9 | < .001 | 3.9 |
| Blast count (<5%, ≥5%) | < .001 | 1.9 | < .001 | 1.8 |
| Complex karyotype | < .001 | 3.2 | .047 | 1.3 |
| MDS with <5% blasts | ||||
| TP53 single hit | .018 | 1.7 | .021 | 1.7 |
| TP53 double hit | < .001 | 4.9 | .041 | 2.2 |
| Complex karyotype | < .001 | 7.0 | < .001 | 5.2 |
| MDS with ≥5% but <10% blasts | ||||
| TP53 single hit | .028 | 2.2 | .026 | 2.3 |
| TP53 double hit | < .001 | 12.1 | < .001 | 9.2 |
| Complex karyotype | < .001 | 4.1 | ns | — |
| MDS with ≥10% but <20% blasts | ||||
| TP53 single hit | n.s. | — | — | — |
| TP53 double hit | < .001 | 5.6 | .004 | 4.6 |
| Complex karyotype | < .001 | 3.2 | ns | — |
| AML | ||||
| TP53 single hit | .039 | 1.5 | .044 | 1.6 |
| TP53 double hit | < .001 | 4.4 | < .001 | 4.2 |
| Complex karyotype | < .001 | 2.6 | n.s. | — |
| . | Univariate . | Multivariate . | ||
|---|---|---|---|---|
| P value . | HR . | P value . | HR . | |
| Without TP53 alteration | ||||
| Blast count (<5%, ≥5%) | < .001 | 1.8 | < .001 | 1.8 |
| Complex karyotype | .038 | 1.6 | ns | — |
| TP53 single hit | ||||
| Blast count (<5%, ≥5%) | .007 | 2.2 | .013 | 2.2 |
| Complex karyotype | .035 | 1.5 | n.s. | — |
| TP53 double hit | ||||
| Blast count (<5%, ≥5%) | .008 | 2.9 | .008 | 2.9 |
| Complex karyotype | ns | — | — | — |
| . | Univariate . | Multivariate . | ||
|---|---|---|---|---|
| P value . | HR . | P value . | HR . | |
| Without TP53 alteration | ||||
| Blast count (<5%, ≥5%) | < .001 | 1.8 | < .001 | 1.8 |
| Complex karyotype | .038 | 1.6 | ns | — |
| TP53 single hit | ||||
| Blast count (<5%, ≥5%) | .007 | 2.2 | .013 | 2.2 |
| Complex karyotype | .035 | 1.5 | n.s. | — |
| TP53 double hit | ||||
| Blast count (<5%, ≥5%) | .008 | 2.9 | .008 | 2.9 |
| Complex karyotype | ns | — | — | — |
ns, not significant.