Modifed CALGB 10403 regimen
| Induction |
| Vincristine: 1.5mg/m2 (max, 2 mg) on days 1, 8, 15, and 22 |
| Daunorubicin: 25 mg/m2 on days 1, 8, 15, and 22 |
| Dexamethasone: 10 mg/m2 from days 1 to 7 and from days 15 to 21 |
| E coli asparaginase: 6000 UI/m2 on days 3, 5, 7, 9, 11, and 13 or pegaspargase: 2500 UI/m2 on day 4 (max, 3750 UI) |
| Rituximab: 375 mg/m2 on day 8 |
| Consolidation 1 |
| Rituximab: 375 mg/m2 on days 1 and 29 |
| Cyclophosphamide: 1000 mg/m2 on days 1 and 29 |
| Cytarabine: 75 mg/m2 on days 1-4, 8-11, 29-32, and 36-39 |
| 6-Mercaptopurine: 60 mg/m2 on days 1-14 and 29-42 |
| Vincristine: 1.5 mg/m2 (max, 2mg) on days 8, 15, 43, and 50 |
| E coli asparaginase: 6000 UI/m2 on days 15, 17, 19, 21, 23, 25, 43, 45, 47, 49, 51 and 53 or pegaspargase: 2500 UI/m2 on days 15 and 43 (max, 3750 UI) |
| Consolidation 2 |
| Rituximab: 375 mg/m2 on days 1 and 21 |
| Methotrexate: 100 mg/m2 on day 1, 150 mg/m2 on day 11, 200 mg/m2 on day 21, 250 mg/m2 on day 31, and 300 mg/m2 on day 41 |
| E coli asparaginase: 6000 UI/m2 on days 2, 4, 6, 8, 10, 12, 22, 24, 26, 28, 30 and 32 or pegaspargase: 2500 UI/m2 on days 2 and 22 (max, 3750 UI) |
| Delayed intensification |
| Rituximab: 375 mg/m2 on days 1, 29, and 50 |
| Vincristine: 1.5 mg/m2 (max, 2 mg) on days 1, 8, 15, 43, and 50 |
| Doxorubicin: 25 mg/m2 on days 1, 8, and 15 |
| Dexamethasone: 10 mg/m2 from days 1 to 7 and from days 15 to 21 |
| E coli asparaginase: 6000 UI/m2 on days 3, 5, 7, 9, 11, 13, 43, 45, 47, 49, 51 and 53 or pegaspargase: 2500 UI/m2 on days 4 and 43 (max, 3750 UI) |
| Cyclophosphamide: 1000 mg/m2 on day 29 |
| Cytarabine: 75 mg/m2 from days 29 to 32 and from days 36 to 39 |
| 6-mercaptopurine: 60 mg/m2 from days 29 to 42 |
| Maintenance (2 y) |
| Vincristine: 1.5 mg/m2 (max, 2 mg) on day 1, monthly |
| Dexamethasone: 6 mg/m2 from days 1 to 5, monthly |
| 6-mercaptopurine: 75 mg/m2 daily |
| Methotrexate: 20 mg/m2 weekly |
| Induction |
| Vincristine: 1.5mg/m2 (max, 2 mg) on days 1, 8, 15, and 22 |
| Daunorubicin: 25 mg/m2 on days 1, 8, 15, and 22 |
| Dexamethasone: 10 mg/m2 from days 1 to 7 and from days 15 to 21 |
| E coli asparaginase: 6000 UI/m2 on days 3, 5, 7, 9, 11, and 13 or pegaspargase: 2500 UI/m2 on day 4 (max, 3750 UI) |
| Rituximab: 375 mg/m2 on day 8 |
| Consolidation 1 |
| Rituximab: 375 mg/m2 on days 1 and 29 |
| Cyclophosphamide: 1000 mg/m2 on days 1 and 29 |
| Cytarabine: 75 mg/m2 on days 1-4, 8-11, 29-32, and 36-39 |
| 6-Mercaptopurine: 60 mg/m2 on days 1-14 and 29-42 |
| Vincristine: 1.5 mg/m2 (max, 2mg) on days 8, 15, 43, and 50 |
| E coli asparaginase: 6000 UI/m2 on days 15, 17, 19, 21, 23, 25, 43, 45, 47, 49, 51 and 53 or pegaspargase: 2500 UI/m2 on days 15 and 43 (max, 3750 UI) |
| Consolidation 2 |
| Rituximab: 375 mg/m2 on days 1 and 21 |
| Methotrexate: 100 mg/m2 on day 1, 150 mg/m2 on day 11, 200 mg/m2 on day 21, 250 mg/m2 on day 31, and 300 mg/m2 on day 41 |
| E coli asparaginase: 6000 UI/m2 on days 2, 4, 6, 8, 10, 12, 22, 24, 26, 28, 30 and 32 or pegaspargase: 2500 UI/m2 on days 2 and 22 (max, 3750 UI) |
| Delayed intensification |
| Rituximab: 375 mg/m2 on days 1, 29, and 50 |
| Vincristine: 1.5 mg/m2 (max, 2 mg) on days 1, 8, 15, 43, and 50 |
| Doxorubicin: 25 mg/m2 on days 1, 8, and 15 |
| Dexamethasone: 10 mg/m2 from days 1 to 7 and from days 15 to 21 |
| E coli asparaginase: 6000 UI/m2 on days 3, 5, 7, 9, 11, 13, 43, 45, 47, 49, 51 and 53 or pegaspargase: 2500 UI/m2 on days 4 and 43 (max, 3750 UI) |
| Cyclophosphamide: 1000 mg/m2 on day 29 |
| Cytarabine: 75 mg/m2 from days 29 to 32 and from days 36 to 39 |
| 6-mercaptopurine: 60 mg/m2 from days 29 to 42 |
| Maintenance (2 y) |
| Vincristine: 1.5 mg/m2 (max, 2 mg) on day 1, monthly |
| Dexamethasone: 6 mg/m2 from days 1 to 5, monthly |
| 6-mercaptopurine: 75 mg/m2 daily |
| Methotrexate: 20 mg/m2 weekly |
Max, maximum.