Patient characteristics for 538 patients with ischemic stroke according to JAK2V617F mutation status
| Patient characteristics . | All (N = 538) . | With JAK2V617F (n = 61) . | Without JAK2V617F (n = 477) . | P . |
|---|---|---|---|---|
| Age, mean ± SD | 69.5 ± 10.9 | 70.8 ± 10.7 | 69.3 ± 10.9 | .329 |
| Sex (female), n (%) | 211 (39.2) | 18 (29.5) | 193 (40.5) | .131 |
| BMI, mean ± SD | 26.9 ± 5.6 | 26.6 ± 5.8 | 26.9 ± 5.5 | .683 |
| Smoking active, n (%) | 163 (30.3) | 23 (37.7) | 140 (29.4) | .234 |
| Smoking former, n (%) | 190 (35.3) | 18 (29.5) | 172 (36.1) | .387 |
| Alcohol use above recommendation∗, n (%) | 65 (12.1) | 8 (13.1) | 57 (12) | .835 |
| Comorbidities | ||||
| Diabetes, n (%) | 109 (20.3) | 12 (19.7) | 97 (20.3) | >.99 |
| Hypertension, n (%) | 359 (66.7) | 37 (60.7) | 322 (67.5) | .355 |
| Hyperlipidemia, n (%) | 288 (53.5) | 32 (52.5) | 256 (53.7) | .967 |
| Atrial fibrillation, n (%) | 82 (15.2) | 10 (16.4) | 72 (15.1) | .850 |
| IHD, n (%) | 74 (13.8) | 10 (16.4) | 64 (13.4) | .553 |
| History of IS or TIA, n (%) | 106 (19.7) | 17 (27.9) | 89 (18.7) | .126 |
| History of VTE, n (%) | 12 (2.2) | 2 (3.3) | 10 (2.1) | .635 |
| History of cancer, n (%) | 64 (11.9) | 7 (11.5) | 57 (11.9) | >.99 |
| Admission | ||||
| NIHSS ≥ 6, n (%) | 125 (21.3) | 14 (23.0) | 111 (23.5) | >.99 |
| Infection at admission, n (%) | 61 (11.4) | 5 (8.2) | 56 (11.8) | .523 |
| CRP ≥ 3 mg/L, n (%) | 251 (47.2) | 23 (38.3) | 228 (48.3) | .187 |
| Hemoglobin, g/dL, mean ± SD | 14.1 ± 1.79 | 14.6 ± 1.61 | 14.1 ± 1.8 | .015 |
| Hematocrit, mean ± SD | 0.42 ± 0.05 | 0.44 ± 0.05 | 0.420 ± 0.05 | .006 |
| Platelet count, × 109/L, mean ± SD | 254 ± 88.6 | 294 ± 147 | 248 ± 77.1 | .021 |
| White blood cells, × 109/L, mean ± SD | 8.72 ± 3.17 | 9.18 ± 3.28 | 8.66 ± 3.16 | .246 |
| Hemoglobin above normal†, n (%) | 68 (12.7) | 11 (18.0) | 57 (12.0) | .262 |
| Hematocrit above normal‡, n (%) | 30 (6.1) | 5 (8.5) | 25 (5.8) | .386 |
| Platelet count above normal§, n (%) | 30 (5.7) | 8 (13.6) | 22 (4.7) | .012 |
| White blood cells above normal‖, n (%) | 214 (40.1) | 27 (44.3) | 187 (39.5) | .569 |
| Patient characteristics . | All (N = 538) . | With JAK2V617F (n = 61) . | Without JAK2V617F (n = 477) . | P . |
|---|---|---|---|---|
| Age, mean ± SD | 69.5 ± 10.9 | 70.8 ± 10.7 | 69.3 ± 10.9 | .329 |
| Sex (female), n (%) | 211 (39.2) | 18 (29.5) | 193 (40.5) | .131 |
| BMI, mean ± SD | 26.9 ± 5.6 | 26.6 ± 5.8 | 26.9 ± 5.5 | .683 |
| Smoking active, n (%) | 163 (30.3) | 23 (37.7) | 140 (29.4) | .234 |
| Smoking former, n (%) | 190 (35.3) | 18 (29.5) | 172 (36.1) | .387 |
| Alcohol use above recommendation∗, n (%) | 65 (12.1) | 8 (13.1) | 57 (12) | .835 |
| Comorbidities | ||||
| Diabetes, n (%) | 109 (20.3) | 12 (19.7) | 97 (20.3) | >.99 |
| Hypertension, n (%) | 359 (66.7) | 37 (60.7) | 322 (67.5) | .355 |
| Hyperlipidemia, n (%) | 288 (53.5) | 32 (52.5) | 256 (53.7) | .967 |
| Atrial fibrillation, n (%) | 82 (15.2) | 10 (16.4) | 72 (15.1) | .850 |
| IHD, n (%) | 74 (13.8) | 10 (16.4) | 64 (13.4) | .553 |
| History of IS or TIA, n (%) | 106 (19.7) | 17 (27.9) | 89 (18.7) | .126 |
| History of VTE, n (%) | 12 (2.2) | 2 (3.3) | 10 (2.1) | .635 |
| History of cancer, n (%) | 64 (11.9) | 7 (11.5) | 57 (11.9) | >.99 |
| Admission | ||||
| NIHSS ≥ 6, n (%) | 125 (21.3) | 14 (23.0) | 111 (23.5) | >.99 |
| Infection at admission, n (%) | 61 (11.4) | 5 (8.2) | 56 (11.8) | .523 |
| CRP ≥ 3 mg/L, n (%) | 251 (47.2) | 23 (38.3) | 228 (48.3) | .187 |
| Hemoglobin, g/dL, mean ± SD | 14.1 ± 1.79 | 14.6 ± 1.61 | 14.1 ± 1.8 | .015 |
| Hematocrit, mean ± SD | 0.42 ± 0.05 | 0.44 ± 0.05 | 0.420 ± 0.05 | .006 |
| Platelet count, × 109/L, mean ± SD | 254 ± 88.6 | 294 ± 147 | 248 ± 77.1 | .021 |
| White blood cells, × 109/L, mean ± SD | 8.72 ± 3.17 | 9.18 ± 3.28 | 8.66 ± 3.16 | .246 |
| Hemoglobin above normal†, n (%) | 68 (12.7) | 11 (18.0) | 57 (12.0) | .262 |
| Hematocrit above normal‡, n (%) | 30 (6.1) | 5 (8.5) | 25 (5.8) | .386 |
| Platelet count above normal§, n (%) | 30 (5.7) | 8 (13.6) | 22 (4.7) | .012 |
| White blood cells above normal‖, n (%) | 214 (40.1) | 27 (44.3) | 187 (39.5) | .569 |
AMI, acute myocardial infarction; BMI, body mass index; CRP, C-reactive protein; IHD, ischemic heart disease; IQR, interquartile range; IS, ischemic stroke; SD, standard deviation; TIA, transient ischemic attack; VTE, venous thromboembolism. P values < 0.05 are shown in bold.
>14 units per week, men; >7 units per week, women.
>16.5 g/dL, men; >15.3 g/dL, women.
> 49%, men; >48%, women.
>390 × 109/L.
> 8.8 × 109/L.