Most common AEs (more than 10%) attributed to pembrolizumab and vorinostat
| . | Grade 1 . | Grade 2 . | Grade 3 . | Grade 4 . | n (%) . |
|---|---|---|---|---|---|
| Hypertension | 14 | 9 | 3 | 0 | 26 (81) |
| Fatigue | 18 | 4 | 0 | 0 | 22 (69) |
| Nausea | 20 | 2 | 0 | 0 | 22 (69) |
| Hyponatremia | 21 | 0 | 0 | 0 | 21 (66) |
| Diarrhea | 14 | 2 | 0 | 0 | 16 (50) |
| Abdominal pain | 13 | 1 | 0 | 0 | 14 (44) |
| Platelet count decreased | 12 | 0 | 2 | 0 | 14 (44) |
| Anemia | 11 | 1 | 1 | 0 | 13 (41) |
| White blood cell decreased | 8 | 4 | 1 | 0 | 13 (41) |
| Vomiting | 10 | 2 | 0 | 0 | 12 (38) |
| Neutrophil count decreased | 6 | 3 | 3 | 0 | 12 (38) |
| Hypokalemia | 10 | 1 | 0 | 0 | 11 (34) |
| Rash maculopapular | 10 | 0 | 0 | 0 | 10 (31) |
| Hypophosphatemia | 0 | 7 | 2 | 1 | 10 (31) |
| Weight loss | 7 | 3 | 0 | 0 | 10 (31) |
| Anorexia | 8 | 1 | 0 | 0 | 9 (28) |
| Pruritus | 8 | 0 | 0 | 0 | 8 (25) |
| Headache | 6 | 2 | 0 | 0 | 8 (25) |
| Creatinine increased | 8 | 0 | 0 | 0 | 8 (25) |
| Aspartate aminotransferase increased | 6 | 1 | 0 | 0 | 7 (22) |
| Myalgia | 7 | 0 | 0 | 0 | 7 (22) |
| Dyspepsia | 6 | 0 | 0 | 0 | 6 (19) |
| Constipation | 6 | 0 | 0 | 0 | 6 (19) |
| Arthralgia | 6 | 0 | 0 | 0 | 6 (19) |
| Alanine aminotransferase increased | 5 | 1 | 0 | 0 | 6 (19) |
| Sinus bradycardia | 5 | 0 | 0 | 0 | 5 (16) |
| Alkaline phosphatase increased | 3 | 2 | 0 | 0 | 5 (16) |
| Atrioventricular block first degree | 4 | 0 | 0 | 0 | 4 (13) |
| Gastroesophageal reflux disease | 4 | 0 | 0 | 0 | 4 (13) |
| Lymphocyte count decreased | 0 | 2 | 2 | 0 | 4 (13) |
| Back pain | 3 | 1 | 0 | 0 | 4 (13) |
| Hypothyroidism | 2 | 2 | 0 | 0 | 4 (13) |
| Alopecia | 4 | 0 | 0 | 0 | 4 (13) |
| . | Grade 1 . | Grade 2 . | Grade 3 . | Grade 4 . | n (%) . |
|---|---|---|---|---|---|
| Hypertension | 14 | 9 | 3 | 0 | 26 (81) |
| Fatigue | 18 | 4 | 0 | 0 | 22 (69) |
| Nausea | 20 | 2 | 0 | 0 | 22 (69) |
| Hyponatremia | 21 | 0 | 0 | 0 | 21 (66) |
| Diarrhea | 14 | 2 | 0 | 0 | 16 (50) |
| Abdominal pain | 13 | 1 | 0 | 0 | 14 (44) |
| Platelet count decreased | 12 | 0 | 2 | 0 | 14 (44) |
| Anemia | 11 | 1 | 1 | 0 | 13 (41) |
| White blood cell decreased | 8 | 4 | 1 | 0 | 13 (41) |
| Vomiting | 10 | 2 | 0 | 0 | 12 (38) |
| Neutrophil count decreased | 6 | 3 | 3 | 0 | 12 (38) |
| Hypokalemia | 10 | 1 | 0 | 0 | 11 (34) |
| Rash maculopapular | 10 | 0 | 0 | 0 | 10 (31) |
| Hypophosphatemia | 0 | 7 | 2 | 1 | 10 (31) |
| Weight loss | 7 | 3 | 0 | 0 | 10 (31) |
| Anorexia | 8 | 1 | 0 | 0 | 9 (28) |
| Pruritus | 8 | 0 | 0 | 0 | 8 (25) |
| Headache | 6 | 2 | 0 | 0 | 8 (25) |
| Creatinine increased | 8 | 0 | 0 | 0 | 8 (25) |
| Aspartate aminotransferase increased | 6 | 1 | 0 | 0 | 7 (22) |
| Myalgia | 7 | 0 | 0 | 0 | 7 (22) |
| Dyspepsia | 6 | 0 | 0 | 0 | 6 (19) |
| Constipation | 6 | 0 | 0 | 0 | 6 (19) |
| Arthralgia | 6 | 0 | 0 | 0 | 6 (19) |
| Alanine aminotransferase increased | 5 | 1 | 0 | 0 | 6 (19) |
| Sinus bradycardia | 5 | 0 | 0 | 0 | 5 (16) |
| Alkaline phosphatase increased | 3 | 2 | 0 | 0 | 5 (16) |
| Atrioventricular block first degree | 4 | 0 | 0 | 0 | 4 (13) |
| Gastroesophageal reflux disease | 4 | 0 | 0 | 0 | 4 (13) |
| Lymphocyte count decreased | 0 | 2 | 2 | 0 | 4 (13) |
| Back pain | 3 | 1 | 0 | 0 | 4 (13) |
| Hypothyroidism | 2 | 2 | 0 | 0 | 4 (13) |
| Alopecia | 4 | 0 | 0 | 0 | 4 (13) |