Statistical analysis of the 8 genes compared between central and institutional laboratories
| Feature . | Overall agreement∗ (%, 95% CI) . | Sensitivity† (%, 95% CI) . | Specificity‡ (%, 95% CI) . | Overall κ§ (95% CI) . |
|---|---|---|---|---|
| DNMT3A | 190/194 (97.9, 94.8-99.4) | 51/54 (94.4, 84.6-98.8) | 139/140 (99.3, 96.1-100) | 0.906 (0.815-0.996) |
| FLT3 | 192/194 (99.0, 96.3-99.9) | 35/37 (94.6, 81.8-99.3) | 157/157 (100, 97.7-100) | 0.945 (0.869-1) |
| IDH1 | 193/194 (99.5, 97.2-100) | 21/22 (95.5, 77.2-99.9) | 172/172 (100, 97.9-100) | 0.948 (0.847-1) |
| IDH2 | 192/194 (99.0, 96.3-99.9) | 44/45 (97.8, 88.2-99.9) | 148/149 (99.3, 96.3-100) | 0.973 (0.934-1) |
| NPM1 | 194/194 (100, 98.1-100) | 45/45 (100, 92.1-100) | 149/149 (100, 97.6-100) | 1 |
| TET2 | 190/194 (97.9, 94.8-99.4) | 33/34 (97.1, 84.7-99.9) | 157/160 (98.1, 94.6-99.6) | 0.932 (0.865-0.999) |
| TP53 | 187/194 (96.4, 92.7-98.5) | 40/45 (88.9, 75.9-96.3) | 147/149 (98.7, 95.2-99.8) | 0.906 (0.834-0.978) |
| WT1 | 190/194 (97.9, 94.8-99.4) | 8/11 (72.7, 39.0-94.0) | 182/183 (99.5, 97.0-100) | 0.848 (0.679-1.017) |
| Feature . | Overall agreement∗ (%, 95% CI) . | Sensitivity† (%, 95% CI) . | Specificity‡ (%, 95% CI) . | Overall κ§ (95% CI) . |
|---|---|---|---|---|
| DNMT3A | 190/194 (97.9, 94.8-99.4) | 51/54 (94.4, 84.6-98.8) | 139/140 (99.3, 96.1-100) | 0.906 (0.815-0.996) |
| FLT3 | 192/194 (99.0, 96.3-99.9) | 35/37 (94.6, 81.8-99.3) | 157/157 (100, 97.7-100) | 0.945 (0.869-1) |
| IDH1 | 193/194 (99.5, 97.2-100) | 21/22 (95.5, 77.2-99.9) | 172/172 (100, 97.9-100) | 0.948 (0.847-1) |
| IDH2 | 192/194 (99.0, 96.3-99.9) | 44/45 (97.8, 88.2-99.9) | 148/149 (99.3, 96.3-100) | 0.973 (0.934-1) |
| NPM1 | 194/194 (100, 98.1-100) | 45/45 (100, 92.1-100) | 149/149 (100, 97.6-100) | 1 |
| TET2 | 190/194 (97.9, 94.8-99.4) | 33/34 (97.1, 84.7-99.9) | 157/160 (98.1, 94.6-99.6) | 0.932 (0.865-0.999) |
| TP53 | 187/194 (96.4, 92.7-98.5) | 40/45 (88.9, 75.9-96.3) | 147/149 (98.7, 95.2-99.8) | 0.906 (0.834-0.978) |
| WT1 | 190/194 (97.9, 94.8-99.4) | 8/11 (72.7, 39.0-94.0) | 182/183 (99.5, 97.0-100) | 0.848 (0.679-1.017) |