LP and B-cell spatial variables and Fan pattern according to treatment response
| . | good . | poor . | P/alpha’/r . |
|---|---|---|---|
| Patients (total) | 33 | 20 | NA |
| Females (typical pattern) | 4 | 5 | NA |
| Females (variant pattern) | 4 | 2 | NA |
| Males (typical pattern) | 19 | 5 | NA |
| Males (variant pattern) | 6 | 8 | NA |
| Fan classes (variant / typical) | 10 / 23 | 10 / 10 | 0.24 |
| Age, y | 11.4 (3.6-17.9) | 13.45 (4.9-17.6) | 0.61 |
| menclus, cells/cluster | 161.5 (64.5) | 87.5 (56) | 0.0012/0.008∗ /0.45 |
| tumorD, cells/mm2 | 61.3 (32.4) | 40.6 (23.2) | 0.0049/0.01∗ /0.39 |
| madclus, cells/cluster | 60.8 (19.8) | 46.7 (16.5) | 0.017/0.0125 |
| LPm3, μm | 74.4 (22.8) | 85 (17.6) | 0.071/0.017 |
| LPmad3, μm | 38.5 (14.6) | 45 (15.2) | 0.14/0.025 |
| Nuclear area, μm2 | 117.4 (14.1) | 124.2 (21.5) | 0.27/0.05 |
| bcellD, cells/mm2 | 3756.2 (2157.8) | 2803 (1594.3) | 0.14 |
| MdistB, μm | 6.4 (0.5) | 6.5 (0.4) | 0.23 |
| McrossLPb, μm | 12.5 (2.7) | 13.1 (3.3) | 0.4 |
| otherD, cells/mm2 | 10 973.6 (2 192.2) | 11 151 (2989.8) | 0.79 |
| . | good . | poor . | P/alpha’/r . |
|---|---|---|---|
| Patients (total) | 33 | 20 | NA |
| Females (typical pattern) | 4 | 5 | NA |
| Females (variant pattern) | 4 | 2 | NA |
| Males (typical pattern) | 19 | 5 | NA |
| Males (variant pattern) | 6 | 8 | NA |
| Fan classes (variant / typical) | 10 / 23 | 10 / 10 | 0.24 |
| Age, y | 11.4 (3.6-17.9) | 13.45 (4.9-17.6) | 0.61 |
| menclus, cells/cluster | 161.5 (64.5) | 87.5 (56) | 0.0012/0.008∗ /0.45 |
| tumorD, cells/mm2 | 61.3 (32.4) | 40.6 (23.2) | 0.0049/0.01∗ /0.39 |
| madclus, cells/cluster | 60.8 (19.8) | 46.7 (16.5) | 0.017/0.0125 |
| LPm3, μm | 74.4 (22.8) | 85 (17.6) | 0.071/0.017 |
| LPmad3, μm | 38.5 (14.6) | 45 (15.2) | 0.14/0.025 |
| Nuclear area, μm2 | 117.4 (14.1) | 124.2 (21.5) | 0.27/0.05 |
| bcellD, cells/mm2 | 3756.2 (2157.8) | 2803 (1594.3) | 0.14 |
| MdistB, μm | 6.4 (0.5) | 6.5 (0.4) | 0.23 |
| McrossLPb, μm | 12.5 (2.7) | 13.1 (3.3) | 0.4 |
| otherD, cells/mm2 | 10 973.6 (2 192.2) | 11 151 (2989.8) | 0.79 |
Results are presented as the median (MAD), except for age, which is presented as the median (min-max). P is Fisher exact test P value (Fan) or Mann-Whitney U test P value (other variables), alpha’ is the local significance level, adjusted using the Bonferroni-Holm method to attain a target level of 0.05, for 6 focal variables (indicated in bold). The Wilcoxon effect size r was calculated for significance tests.
Indicate significant differences between the groups.