Genes mutated by targeted next generation sequencing (NGS) in greater than or equal to 5% of t-NPM1 AML and/or t-AML cases, in comparison to dn-NPM1 AML
| Gene . | t-NPM1, % (mutant/wild-type cases) . | t-AML, % (mutant/wild-type cases) . | P value∗ t-NPM1 vs t-AML . | dn-NPM1 AML, % (mutant/wild-type cases) . | P value∗ dn-NPM1 AML vs t-AML . |
|---|---|---|---|---|---|
| DNMT3A | 43 (46/107) | 13 (22/163) | <.0001 | 48 (42/88) | .56 |
| TET2 | 40 (43/107) | 11 (18/163) | <.0001 | 30 (26/88) | .134 |
| FLT3 | |||||
| Indel† | 16 (17/107) | 8 (12/158) | .044 | 30 (26/88) | .025 |
| TK | 16 (17/107) | 3 (4/127) | .0009 | 20 (17/86) | .569 |
| IDH2 | 19 (20/107) | 8 (13/156) | .0145 | 18 (16/88) | 1 |
| PTPN11 | 18 (19/107) | 0 (0/100) | <.0001 | 9 (8/88) | .097 |
| IDH1 | 15 (16/107) | 7 (10/155) | .034 | 7 (6/86) | .11 |
| SRSF2 | 10 (11/107) | 7 (9/134) | .35 | 7 (6/88) | .45 |
| NRAS | 8 (9/107) | 10 (15/153) | .83 | 10 (9/87) | .80 |
| KRAS | 7 (7/107) | 7 (10/153) | 1 | 2 (2/86) | .30 |
| WT1 | 6 (6/107) | 5 (6/119) | 1 | 6 (5/85) | 1 |
| STAG2 | 5 (5/107) | 8 (5/66) | .508 | 6 (5/81) | .748 |
| ASXL1 | 4 (4/107) | 11 (18/163) | .04 | 2 (2/88) | .69 |
| PPM1D | 4 (4/107) | 5 (3/60) | .70 | 1 (1/88) | .38 |
| BCOR | 3 (3/107) | 7 (8/120) | .224 | 2 (2/86) | 1 |
| TP53 | 3 (3/107) | 26 (42/161) | <.0001 | 0 (0/88) | .253 |
| RUNX1 | 1 (1/107) | 12 (19/154) | .0005 | 0 (0/88) | 1 |
| Gene . | t-NPM1, % (mutant/wild-type cases) . | t-AML, % (mutant/wild-type cases) . | P value∗ t-NPM1 vs t-AML . | dn-NPM1 AML, % (mutant/wild-type cases) . | P value∗ dn-NPM1 AML vs t-AML . |
|---|---|---|---|---|---|
| DNMT3A | 43 (46/107) | 13 (22/163) | <.0001 | 48 (42/88) | .56 |
| TET2 | 40 (43/107) | 11 (18/163) | <.0001 | 30 (26/88) | .134 |
| FLT3 | |||||
| Indel† | 16 (17/107) | 8 (12/158) | .044 | 30 (26/88) | .025 |
| TK | 16 (17/107) | 3 (4/127) | .0009 | 20 (17/86) | .569 |
| IDH2 | 19 (20/107) | 8 (13/156) | .0145 | 18 (16/88) | 1 |
| PTPN11 | 18 (19/107) | 0 (0/100) | <.0001 | 9 (8/88) | .097 |
| IDH1 | 15 (16/107) | 7 (10/155) | .034 | 7 (6/86) | .11 |
| SRSF2 | 10 (11/107) | 7 (9/134) | .35 | 7 (6/88) | .45 |
| NRAS | 8 (9/107) | 10 (15/153) | .83 | 10 (9/87) | .80 |
| KRAS | 7 (7/107) | 7 (10/153) | 1 | 2 (2/86) | .30 |
| WT1 | 6 (6/107) | 5 (6/119) | 1 | 6 (5/85) | 1 |
| STAG2 | 5 (5/107) | 8 (5/66) | .508 | 6 (5/81) | .748 |
| ASXL1 | 4 (4/107) | 11 (18/163) | .04 | 2 (2/88) | .69 |
| PPM1D | 4 (4/107) | 5 (3/60) | .70 | 1 (1/88) | .38 |
| BCOR | 3 (3/107) | 7 (8/120) | .224 | 2 (2/86) | 1 |
| TP53 | 3 (3/107) | 26 (42/161) | <.0001 | 0 (0/88) | .253 |
| RUNX1 | 1 (1/107) | 12 (19/154) | .0005 | 0 (0/88) | 1 |