Cytogenetics of primary and relapsed/refractory ML-DS blasts
| Cytogenetic abnormalities . | Primary ML-DS (n = 31) . | Relapsed/refractory ML-DS (n = 31) . | |
|---|---|---|---|
| Trisomy 8 | 8 | 10 | |
| Trisomy 21, acquired | 6 | 6 | |
| Chromosome 17 | Monosomy 17 | 0 | 5 |
| del(17p) | 0 | 2 | |
| Chromosome 7 | Monosomy 7 | 3 | 4 |
| i(7)(q10) | 3 | 4 | |
| del(7p) | 1 | 1 | |
| Cytogenetic abnormalities . | Primary ML-DS (n = 31) . | Relapsed/refractory ML-DS (n = 31) . | |
|---|---|---|---|
| Trisomy 8 | 8 | 10 | |
| Trisomy 21, acquired | 6 | 6 | |
| Chromosome 17 | Monosomy 17 | 0 | 5 |
| del(17p) | 0 | 2 | |
| Chromosome 7 | Monosomy 7 | 3 | 4 |
| i(7)(q10) | 3 | 4 | |
| del(7p) | 1 | 1 | |
Among 31 patients who had paired karyotypes available from both time-points, 18 gained abnormalities, 2 lost abnormalities, and 11 showed no change at the time of diagnosis of r/r ML-DS compared to those at the primary diagnosis. The table summarizes the subset of changes present in more than 1 patient.