Mixed model analysis comparing log10-transformed serum TARC levels between HL cases and their respective controls
| Variable . | No. in analysis . | Effect size . | SE . | P value . | Time to diagnosis, y . |
|---|---|---|---|---|---|
| All patients | 103 | 1.27 | 0.073 | 1.2 × 10-47 | 6.35 |
| Subtype | |||||
| Nodular sclerosis | 67 | 1.37 | 0.084 | 3.5 × 10-43 | 6.23 |
| Mixed cellularity | 13 | 0.92 | 0.19 | 1.6 × 10-6 | 4.0 |
| Classic NOS | 23 | 1.25 | 0.13 | 1.3 × 10-18 | 8.33 |
| EBV status∗ | |||||
| Negative | 76 | 1.35 | 0.079 | 1.6 × 10-46 | 6.14 |
| Positive | 23 | 0.88 | 0.13 | 7.9 × 10-11 | 8.0 |
| Variable . | No. in analysis . | Effect size . | SE . | P value . | Time to diagnosis, y . |
|---|---|---|---|---|---|
| All patients | 103 | 1.27 | 0.073 | 1.2 × 10-47 | 6.35 |
| Subtype | |||||
| Nodular sclerosis | 67 | 1.37 | 0.084 | 3.5 × 10-43 | 6.23 |
| Mixed cellularity | 13 | 0.92 | 0.19 | 1.6 × 10-6 | 4.0 |
| Classic NOS | 23 | 1.25 | 0.13 | 1.3 × 10-18 | 8.33 |
| EBV status∗ | |||||
| Negative | 76 | 1.35 | 0.079 | 1.6 × 10-46 | 6.14 |
| Positive | 23 | 0.88 | 0.13 | 7.9 × 10-11 | 8.0 |
Case-control pair identifier and individual identifier within a pair were accounted for as random effects. Effect size and SE show the difference between cases and respective controls in log10-transformed TARC levels at the time of diagnosis. Time to diagnosis indicates the calculated time point at which TARC levels start to increase in cases.
NOS, not otherwise specified.
For 4 cases, EBV status was not available.